Applera Corporation

Mds Inc.

Peter Juhasz

Andrew J Tomlinson

Stephen A Martin

Armin Graber

Michael P Donegan

Dale H Patterson

Perumanath H Nair

A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (&#x3c;1,000 daltons) of a MALDI-MS spectrum.

Reduction of matrix interference for MALDI mass spectrometry analysis

In various embodiments, the methods for analyzing a sample are provided utilizing a result dependent acquisition strategy. In various embodiments, methods for analyzing a sample are provided wherein the sample is first analyzed by MALDI and MS to produce a first result that is then used to determine a second analysis that is used to analyze the sample again by MALDI and MS/MS or MSto produce a second result.

Method for characterizing biomolecules utilizing a result driven strategy

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Natick, MA, United States of America

Peter Juhasz