Organo Corporation

Other

Isis Innovation Limited

Brenner, Paolo

Peter John Friend

Stuart Brian William Kay

Constantin Coussios

Leslie James Russell

Philip David Canner

David George Robinson

Sebastien Antoine Yves Cuvelier

Peter Alan Salkus

Jonathan Richard Oakley

Constantin-C Coussios

Michael A Rees

Andrew Butler

Hendrik J Schuurman

Emanuele Luigi Maria Cozzi

Francoise Richard

Guy Taccard

David James Graham White

John Wallwork

Paolo Brenner

Françoise Richard

A disposable set of components for an organ perfusion system comprising a fluid supply duct for supplying fluid to the organ, a fluid removal duct for removing fluid from the organ, and a surrogate organ removably connected between the fluid supply duct and the fluid removal duct so as to form a fluid circuit, so that fluid can be circulated in the circuit in preparation for connection of the organ.

Organ perfusion systems

An organ perfusion system comprises: a perfusion fluid circuit () arranged to circulate perfusion fluid through the organ; a surrogate organ () arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (), or a flow meter (). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (), and means () to measure the amount of fluid secreted by or leaked from the organ, may also be provided.

A perfusion system for the perfusion of an organ comprises a perfusion fluid circuit () for circulating perfusion fluid through the organ, oxygenation means () for adding oxygen into the perfusion fluid, and an oxygen supply arranged to supply oxygen to the oxygenation means. The oxygen supply comprises an oxygen concentrator.

Oxygen supply for organ perfusion systems

A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2 transcription inhibitor and immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts, and pharmaceutically acceptable diluents or carriers, and a method of preventing hyperacute rejection, reducing early graft damage, improving early xenograft function and promoting long term survival of said transgenic xenografts comprising the steps of i) contacting the body fluid removed from a human recipient with a xenoantigenic material which is bound to a biocompatible solid support, ii) reintroducing the treated body fluid into the recipient, and iii) treating the recipient with said pharmaceutical composition.

Combinations of immunosuppressive agents for the treatment or prevention of graft rejections

Apparatus and methods of operation of apparatus for the extracorporeal perfusion of organs are provided which support viability and function of an organ such as a liver, generally outside the body. Blood is supplied as described herein to an organ such as a liver under physiological pressure but without forcing blood flow at any particular rate such that the organ is allowed to auto-regulate blood flow. This allows for organ preservation or resuscitation prior to transplantation, maintenance of organs for use in experimental study of isolated liver physiology, and treatment of patients suffering from organ failure.

Methods and means for extracorporeal organ perfusion

Growing community of inventors

Oxford, United Kingdom

Peter John Friend