General Electric Company

Peter John Bonitatibus, Jr

Robert Edgar Colborn

Andrew Soliz Torres

Matthew David Butts

Amit Mohan Kulkarni

Bruce Allan Hay

Francis Johnson

Brian Christopher Bales

Binil Itty Ipe Kandapallil

Michael Ernest Marino

Paul William Buckley

Judson Sloan Marte

John Thomas Leman

Min Zou

Ying Zhou

Job Thomas Rijssenbeek

Daniel Eugene Meyer

Rebecca Suzanne Northey

David Cheney deMoulpied

Christina Chen

Michacl Ernest Marino

Chiaki Treynor

Mohammed Haouaoui

A method for selectively removing an aluminum-silicon coating fired on a surface of a metallic structure is described. The method includes the step of contacting the coating with molten potassium hydroxide (KOH), under conditions sufficient to remove the coating without substantially affecting the metallic surface. Methods for preparing a magnetic component are also described. They involve masking pre-selected regions of the surface of the component, using an aluminum-silicon coating that is fired onto the surface, prior to a nitriding step. The coating is then removed according to the procedure outlined herein.

Process for removing aluminum-silicon coatings from metallic structures, and related processes for preparing magnetic components

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.

Nanoparticle contrast agents for diagnostic imaging

A method of making a nanocomposite permanent magnet is provided. The method comprises applying an extreme shear deformation to hard magnetic phase nanoparticles and soft magnetic phase nanoparticles to align at least a portion of the hard phase magnetic particles and to produce a nanocomposite permanent magnet.

Nanocomposite permanent magnets and methods of making the same

A method of maintaining the performance level of an electrochemical cell is described. The cell usually includes a negative electrode that includes an alkali metal; a positive electrode that includes at least one transition metal halide; a molten salt electrolyte based on an alkali metal haloaluminate; and a sodium ion-conducting solid electrolyte partitioning the positive electrode from the negative electrode. The method is based on a treatment regimen that includes the step of applying a series of electrical cycles to the cell, wherein the series includes at least one deep discharge of the cell. Each discharge of the cell is usually followed by recharging the cell to its available capacity.

Method for maintaining the performance level of an electrochemical cell

A method of synthesizing magnetic nanoparticles comprising soft magnetic phases is provided, wherein the method comprises degassing a first mixture at a temperature in a range from about 80&#xb0; C. to 130&#xb0; C. The first mixture comprises a solvent, a compound comprising iron, cobalt, or combinations thereof dissolved in the solvent, and an organic component comprising a fatty acid or an amine. Degassing the first mixture is followed by adding a capping ligand to the first mixture under inert atmosphere to form a second mixture; adding a reducing agent to the second mixture at a temperature in a processing temperature range from about 250&#xb0; C. to about 350&#xb0; C. to form a third mixture; and incubating the third mixture at a temperature within the processing temperature range to form nanoparticles comprising a soft magnetic phase.

Soft magnetic phase nanoparticles preparations and associated methods thereof

The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites. Included herein are methods for forming such agents, comprising forming an ensemble of core/shell nanoparticles, wherein the mean diameter of the ensemble of core/shell nanoparticles is selected so as to render the nanoparticles in the ensemble substantially clearable by a mammalian kidney.

Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same

The present invention provides a trialkoxysilane having structure I wherein Ris independently at each occurrence a C-Calkyl group; Ris independently at each occurrence a hydrogen or a C-Calkyl group; Ris a C-Caliphatic radical, a C-Caromatic radical, or a C-Ccycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; t is 0, 1 or 2; and Xrepresents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.

Nanoparticulate compositions for diagnostic imaging

Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.

The present invention provides a trialkoxysilanes having structure I wherein Rand Rare independently at each occurrence a C-Calkyl group; Ris independently at each occurrence a hydrogen or a C-Calkyl group; Ris a C-Caliphatic radical, a C-Caromatic radical, or a C-Ccycloaliphatic group; n is 0, 1, 2 or 3; q is 1, 2 or 3; and Xrepresents a charge balancing counterion. The trialkoxysilanes are useful for the preparation of nanoparticulate diagnostic imaging agent compositions.

The present invention provides novel metal alginates prepared from non-cross-linked alginate monomers such as sodium alginate and an aqueous solution of a group 4, 5, or 6 metal oxyhalide. The novel group 4, 5, and 6 metal alginates are useful in the preparation of cell culture supports, exhibit useful X-ray contrast properties, and exhibit unanticipated stability to standard autoclave conditions relative to known metal alginates such as calcium alginate. In general, the novel metal alginates provided by the present invention offer features and properties not observed in known metal alginates such as calcium or barium alginates.

Metal alginate hydrogel and articles thereof

Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.

Growing community of inventors

Saratoga Springs, NY, United States of America

Peter John Bonitatibus, Jr