Interleukin Genetics, Inc.

Imperial College Innovations Limited

Imperial College of Science, Technology and Medicine

Boditech Diagnostics Limited

Peter John Barnes

Gordon W Duff

Samson Lim

Francesco Saverio Di Giovine

Paolo Paredi

Louise Elizabeth Donnelly

Franco Di Giovine

Sergei A Kharitonov

Richard Edward Russell

A method is provided for treating inflammatory respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). The method involves administration, preferably oral or pulmonary administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.

Administration of resveratrol to treat inflammatory respiratory disorders

Methods and kits for detecting polymorphisms that are predictive of a subject's susceptibility to developing an obstructive airway disease, such as asthma, as well as for determining the relative severity of the disease are described. Assays for identify therapeutics are also described.

Diagnostics and therapeutics for an obstructive airway disease

The present invention provides a novel method for the early prediction of a propensity to develop chronic obstructive airway disorders such as asthma. The present invention also provides kits for the early determination of the propensity to develop such a disorder. The method consists of detecting the presence of one or more alleles of an IL-1B haplotype, specifically the IL-1b (+3954) and the IL-1B (-511) loci. The presence of allele 2 at the IL-1b (+3954) locus indicates increased risk for a chronic obstructive airway disorder. The presence of allele 2 at the IL-1B (-511) locus indicates susceptibility to more severe expression of chronic obstructive airway disorders.

Method and kit for predicting susceptibility to asthma

A breath sample reservoir comprises a container for storing a sample of breath, the container defining a sealable aperture through which the breath sample can be introduced into the container, the container being provided with a bactericidal material to inhibit reproduction of bacteria within the container.

Breath collection and storage

Growing community of inventors

London, United Kingdom

Peter John Barnes