Other

Arizona State University

The Scripps Research Institute

University of Washington

Gene Tools, LLC

Engineering Arts LLC

Peter Jan Wiktor

Joshua LaBaer

Blake Hannaford

Deirdre Meldrum

Donald B Snow

Bharath Takulapalli

Ji Qiu

Clinton S Potter

Tilak Jain

Peter A Kahn

Bridget Carragher

Mitch Magee

Ray Kraft

Ronald Seubert

Neal A Friedman

Maynard V Olson

Al Brunner

Peter Kahn

A microreactor array platform and method for sealing a reagent in microreactors of an array of microreactors are provided. The microreactor array platform includes an array of microreactors, and a sealing film having a first surface and an opposite second surface, the sealing film configured to movably seal the array of microreactors. The microreactor array platform also includes an injector for delivering a reagent into the array of microreactors via a fluid path between the array and the second surface of the sealing film, and an applicator for directing a sealing liquid against the first surface of the sealing film. The microreactor array platform further includes a system for creating a pressure differential between the reagent in the injector and a space between the array of microreactors and the second surface of the sealing film.

Microreactor array platform

A manipulator system having a positioner having a primary rail, a first coupling linkage, and a second coupling linkage. The first coupling linkage couples the primary rail to a base and positions the primary rail along a first plane. The system has another positioner having a secondary rail, a third coupling linkage, and a fourth coupling linkage. The third coupling linkage couples the secondary rail to the base and positions the secondary rail along a second plane which is parallel to the first plane. A common link couples to the primary and secondary rails via linkages. Each of the second and fourth coupling linkages includes a joint for linear motion along the respective rail, and a revolute joint for relative pivoting between the respective rail and the common link. A position and orientation of the common link are adjustable by the joints and revolute joints.

Coupled positioners

The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.

Apparatus and method for producing specimens for electron microscopy

A piezoelectric actuated device for acquiring and dispensing fluid samples is described. Fluid samples are acquired or drawn up into the device by dipping the tip into a fluid and applying an alternating current electrical signal to the piezoelectric element. Removing the tip from the fluid and applying another electrical signal causes drops of fluid to be ejected for non-contact dispensing. The device optionally incorporates a second piezoelectric element functioning as a sensor to detect if it is empty, plugged or working properly. An optional heater, temperature sensor and feedback circuitry regulate the temperature of the device.

Piezoelectric pipetting device

A high precision, small volume fluid processing system employs open ended capillary tubes to meter, aliquot and mix small volumes of sample fluid and reagents. The system has an automatic mechanism for moving the capillary tubes as well as automated sub-systems for incubating and mixing fluids within the capillary tubes.

Precision small volume fluid processing apparatus

Growing community of inventors

Phoenix, AZ, United States of America

Peter Jan Wiktor