Chemwerth, Inc.

Peter J Werth

Xiping Su

Sidney Xi Liang

Lin Yi

The disclosure provides compounds and pharmaceutically acceptable salts thereof of Formula (I) The variables, R, R!-R3 and the A-ring are described herein. A can be a cyclohexyl ring. The compounds are inhibitors of JAK1 Kinase and are useful in methods of treating an allergic, inflammatory, or autoimmune disorders, in a patient, comprising administering a therapeutically effective amount of compound of Formula I or salt thereof, to the patient. The disclosure also provides pharmaceutical formulations containing a compound of Formula I.

Substituted (7H-pyrrolo[2,3-D]pyrimidin-4-yl) amino compounds useful as JAK 1 inhibitors

Methods and intermediates for the synthesis of carprofen and its derivatives starting from cyclohexanone are disclosed.

Growing community of inventors

Woodbridge, CT, United States of America

Peter J Werth