May & Baker, Ltd.

Peter J Warne

Libert C Saunders

Raymond F Collins

Barbara Joyce Broughton

Philip Knowles

David J Lythgoe

Edward Lunt

Keith A Stuttle

Robert K Chambers

Christopher A Ramsden

Francis J Tierney

David W Gilmour

Adnan H Al-Shaar

Diane M Kelsey

Ian McClenaghan

Peter Lowden

Duncan C McDougall

Ethene derivatives

Pyridylaminoethene derivatives of the formula: ##STR1## wherein R.sup.1 is pyridyl, unsubstituted or substituted by one or more substituents R.sup.4 selected from halogen, amino, carboxy, cyano nitro, hydroxy, formyl, trifluoromethyl, aryl, aryloxy, arylthio, benzyloxycarbonylamino, sulphamoyl, tetrazol-5-yl, carbamoyl, thiocarbamoyl, arylcarbamoyl, aroyl, alkyl, alkoxy, alkylthio, alkylsulphonyl, alkylamino, alkylsulphamoyl, arylalkyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, N-benzyloxycarbonyl-N-alkylamino, or dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl, wherein the alkyl groups may together form a ring, and R.sup.2 and R.sup.3 each represents phenyl, unsubstituted or substituted by one or more substituents R.sup.4 as hereinbefore defined, possess antiarthritic properties.

Antiarthritic pyridylaminoethene disulfonyl compounds and use

3-(N,N-Dimethylcarbamoyl)pyrazolo[1,5-a]pyridine of the formula: ##STR1## which is a new compound, possesses pharmacological properties, in particular properties which are indicative of outstanding utility in the treatment of arthritic disorders such as rheumatoid arthritis. The compound can be prepared by reacting a pyrazolo[1,5-a]pyridine-3-carbonyl halide (e.g. chloride) with dimethylamine.

Treating arthritis with 3-(N,N-dimethyl carbamoyl)pyrazolo[1,5-a]pyridine

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Peter J Warne