Abbott Laboratories Corporation

Massachusetts Institute of Technology

Abbott Cardiovascular Systems, Inc.

Peter J Tarcha

Keith R Cromack

Sandra E Burke

John L Toner

Donald J Verlee

Angela M LeCaptain

Karl W Mollison

Thomas E Rohr

Therese Cotton

Richard Quint

Yen-Chih J Chen

Sanjay Shrivastava

James J Markese

David A Pecosky

Bernard N Rospendowski

Angela M Lecaptain

Robert Samuel Langer

Anton G Clifford

Ho-Wah Hui

Mark R Pope

Venkatram R Shastri

Gary E Winter

Charles Jack Fisher

Martin Wong

Terry A Pry

James J Donovan

Mary K Joseph

Daniel D Subotich

C Brent Putman

David R Mees

Ho-Wa Hui

A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to drugs of Formula (I). The drugs of Formula (I) can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs. 

Medical devices containing rapamycin analogs

An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The interventional device has a controlled local areal density of beneficial agent for systemic delivery or delivery to the luminal wall. The local areal density of beneficial agent may be varied along the prosthesis. The interventional device includes overlapping or bifurcated stents having a controlled areal density of beneficial agent.

Prosthesis having varied concentration of beneficial agent

A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step.

One-step phosphorylcholine-linked polymer coating and drug loading of stent

A prodrug compound of a rapamycin analog and methods for inhibiting, treating, and preventing mammalian diseases.

Compounds and methods for treatment and prevention of diseases

A method of making a medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Method of integrating therapeutic agent into a bioerodible medical device

A medical device which is at least partially bio-erodible and which exhibits controlled elution of therapeutic agent.

Integration of therapeutic agent into a bioerodible medical device

A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to, This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances for treatment of vascular disorder

An interventional device for delivery of beneficial agent to a lumen and methods of loading and manufacture of the same, which include a prosthesis loaded with beneficial agent to provide a controlled dosage concentration of beneficial agent to the lumen. The beneficial agent is loaded onto the prosthesis by a fluid-dispenser having a dispensing element capable of dispensing the beneficial agent in discrete droplets, each droplet having a controlled trajectory. The method of loading beneficial agent includes dispensing beneficial agent in a raster format and/or an off-axis format along a dispensing path.

System and method of loading and detecting beneficial agent on a prosthesis

Method of loading beneficial agent to a prosthesis by fluid-jet application

System of loading beneficial agent to a prosthesis by fluid-jet

A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs 

Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices

Growing community of inventors

Lake Villa, IL, United States of America

Peter J Tarcha