Array Biopharma Inc.

Genentech, Inc.

Novartis Ag

Roche Palo Alto LLC

Intermune, Inc.

Peter J Stengel

Weidong Liu

Paul Nichols

Christoph Max Krell

Werner Heinz Pachinger

Daniel Zimmermann

Marian Misun

Daniel Andreas Niederer

Marie-Christine Wolf

Keith Lee Spencer

Sagar Raj Shakya

Travis Remarchuk

Chong Han

Jonathan W Lane

James F Blake

C Gregory Sowell

Jay Bradford Fell

Stacey Spencer

David Askin

John Peter Fischer

Robert Than Hendricks

Steven Wade Andrews

Yutong Jiang

Michelangelo Scalone

Kevin Ronald Condroski

Francis Gosselin

Ian S Mitchell

Rui Xu

Dengming Xiao

Mark C Munson

John E Robinson

Anthony D Piscopio

John A Josey

Lawrence M Blatt

Nicholas C Kallan

Chang Rao

April L Kennedy

Daniel John Watson

Guy P A Vigers

Bruno P Hache

Derrick Juengst

C Todd Eary

Steven Mark Wenglowsky

Scott Miller

Yongxin Han

Paul J Nichols

Zackary D Crane

Bing Wang

April L Bernacki

Peter Mohr

Keena Green

Todd C Eary

Stacey Renee Spencer

The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Preparation of and formulation comprising a MEK inhibitor

The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.

Process for preparing a compound

Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein. 

Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof

The invention provides processes for preparing a compound of formula I and salts thereof, wherein Ris defined herein, and compounds and intermediates of said formula.

Process for making hydroxylated cyclopentylpyrimidine compounds

The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

The invention provides processes for preparing a compound of formula I and salts thereof, wherein Ris defined herein, and compounds and intermediates of said formula. 

The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula:A-L-CRwhere CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

AKT protein kinase inhibitors

Compounds having the formula i wherein m, R, R, Rand Xare herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process. 

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Boulder, CO, United States of America

Peter J Stengel