Sio2 Medical Products, Inc.

Other

Smithkline Beecham Corporation

The Standard Register Company

Csp Technologies, Inc.

Quest Diagnostics Incorporated

Cv Holdings LLC

Si02 Medical Products, Inc.

Quest Diagnostics Investments, Inc.

Peter J Sagona

Robert S Abrams

Robert J Pangborn

Thomas E Fisk

John Thomas Felts

John Ferguson

Jonathan R Freedman

Christopher Weikart

David P O'Bryan

Jean-Pierre Giraud

Joseph W Rogers

Bernard Sol

Michael J Mims

Michael Bucholtz

Bingham H Van Dyke, Jr

Kevin N Constable

Herve Pichot

David F Laurash

Bruce Rabinne

Michael Scott Hutchinson

Adam Stevenson

Jacob N Israelachvili

Benjamin Hunt

Jean Pierre Giraud

Joseph A Jones

Brian Fitzpatrick

Sherry L Bannister

Shawn Kinney

Rod Miller

Johathan R Freedman

Adrian Raiche

David Dwyer

A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOcomposite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O—Si—C covalent bonding, as a proportion of the O—Si—C covalent bonding plus SiObonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiObonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.

SiObarrier for pharmaceutical package and coating process

A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the Oto the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus

A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.

Three-position plungers, film coated plungers and related syringe assemblies

A syringe or other vessel having a substrate surface coated by PECVD is provided. The PECVD coating is made by generating plasma from a gaseous reactant comprising an organosilicon precursor and optionally O. The lubricity, hydrophobicity and/or barrier properties of the coating are set by setting the ratio of the Oto the organosilicon precursor in the gaseous reactant, and/or by setting the electric power used for generating the plasma. In particular, a lubricity coating made by said method is provided. Vessels coated by said method and the use of such vessels protecting a compound or composition contained or received in said coated vessel against mechanical and/or chemical effects of the surface of the uncoated vessel material are also provided.

Syringe with PECVD lubrication

A package including a vessel wherein at least a portion of the vessel wall is made of a double wall material is disclosed. The double wall material comprises an interior polymer layer enclosed by an exterior polymer layer and one of the polymer layers is a layer made of cyclic olefin polymer (COP) resin. The package comprising the double wall, a CVD coating set on the wall, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

Cyclic olefin polymer vessels and vessel coating methods

A container includes an external package and a sealed flexible bag, adapted to hold liquid contents, retained within the external package. The bag is made from a polymer film, which prior to being formed into a bag, was a two dimensional film to which was applied a PECVD SiOx coating.

Packaging for high purity solvents

A convertible plunger is provided comprising an internal portion and a generally cylindrical exterior surface. At least a portion of the exterior surface is maintained in an initial expanded state by a property of the internal portion. The expanded state is reducible to a constricted state by an operation that is applied to the internal portion of the plunger to alter the property. A film coating may also be applied to a sidewall of the sleeve to reduce a sliding friction between the sleeve and barrel. A film coating may also be applied to a nose cone of the plunger to provide a barrier between the plunger and product in the barrel.

Convertible plungers, film coated plungers and related syringe assemblies

Methods for processing a vessel, for example to provide a gas barrier or lubricity, are disclosed. First and second PECVD or other vessel processing stations or devices and a vessel holder comprising a vessel port are provided. An opening of the vessel can be seated on the vessel port. The interior surface of the seated vessel can be processed via the vessel port by the first and second processing stations or devices. Vessel barrier and lubricity coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed. A vessel processing system is also disclosed.

Syringe with PECVD lubricity layer

Syringe with PECVD lubricity layer, apparatus and method for transporting a vessel to and from a PECVD processing station, and double wall plastic vessel

A method for providing a passivation layer or pH protective coating on a substrate surface by PECVD is provided, the method comprising generating a plasma from a gaseous reactant comprising polymerizing gases. The lubricity, passivation, pH protective, hydrophobicity, and/or barrier properties of the passivation layer or pH protective coating are set by setting the ratio of the Oto the organosilicon precursor in the precursor feed, and/or by setting the electric power used for generating the plasma. In particular, a passivation layer or pH protective coating made by the method is provided. Pharmaceutical packages coated by the method and the use of such packages protecting a composition contained in the vessel against mechanical and/or chemical effects of the surface of the package without a passivation layer or pH protective coating material are also provided.

Growing community of inventors

Pottstown, PA, United States of America

Peter J Sagona