Network Equipment Technologies, Inc.

Bloodcenter Research Foundation

The Blood Center of Southeastern Wisconsin

Other

Ensim Corporation

Nokia Ip, Inc.

Digital Asset Enterprises, L.l.c.

Versiti Blood Research Institute Foundation, Inc.

Ipsilon Networks, Inc.

Peter J Newman

Richard H Aster

Pawan Goyal

Amar S Gupta

Gururaj Singh

John L Burnett

Greg Minshall

Eric Hoffman

Fong Ching Liaw

Robert Hinden

Thomas Lyon

Nancy Kirshbaum

Richard J Gumina

Huiying Zhi

Willie T Glover

William Alan Roberson

Clifford James Buckley

Nanyan Zhang

Lawrence B Huston

Sridhar Rao

Sentot S Santoso

A transgenic mouse comprising T30A, S32P, Q33L, N39D, and M470Q mutations in GPIIIa, as well as methods for making the transgenic mouse and methods for using the transgenic mouse to screen test compounds are described.

Murine model of fetal/neonatal alloimmune thrombocytopenia

Methods of creating cells expressing specific platelet alloantigens by combining gene editing techniques and cell culture differentiation or expansion techniques employing pluripotent cells, including the steps of transfecting pluripotent cells with a plasmid encoding one or more guide RNAs targeting within a platelet alloantigen target locus and a nuclease in the presence of an HDR repair oligo and culturing the resulting cells to expand their numbers or to create a differentiated cell type of interest.

Method to bioengineer designer platelets using gene editing and stem cell methodologies

A method and system allows a service provider to provide Intranet services remotely by assigning private virtual servers to customers. Each customer addresses transmissions to one or more private virtual servers using private addresses from the customer's private Intranet. The addresses of different private virtual servers do not have to be unique and may overlap. Customers exchange privately-addressed transmissions with the service provider using tunnels to traverse the local or regional network connecting the customer with the service provider. The service provider routes the transmissions to the relevant private virtual server belonging to the customer that sent the transmission. The service provider also routes privately-addressed transmissions back to individual customers using tunnels.

Enabling a service provider to provide intranet services

According to this invention, a conventional pair of golf gloves is provided with pads across the palm portions thereof which abut the grip portion of a golf club shaft to automatically align the shaft for proper gripping. The guide pads are so positioned across the palm portions of the gloves that when the golf club head is soled on the ground and the upper and lower gripping hands of a golfer wearing the gloves receive the grip portion of the club shaft across the palms of the glove and against the pads, the shaft will lie diagonally across the roots of the fingers and when the hands are closed around the shaft with the guide pads cradling the grip portion of the golf club distal from the golf club head, an automatic proper gripping of the golf club will be insured. The guide pads are substantially parallel to the transverse creases of the hand, lying diagonally across the roots of the fingers. The pad on the first glove spans substantially the entire palm of the hand. The pad on the second glove spans from about the outer edge of the index finger to about the middle of the metacarpal-phalangeal joint of the second finger of the hand. Differences between the lengths of the pads allow the use of the gloves without one pad impinging upon the other.

Golf gloves

Novel, substantially isolated isoforms of human platelet-endothelial cell adhesion molecule-1's, DNAs coding for transcripts that encode the novel isoforms and others, including a previously identified soluble isoform, methods of using such DNAs to make isoforms by expressing the DNA's, and promoter segments controlling transcription of human platelet-endothelial cell adhesion molecule-1 genes are provided. The novel isoforms differ from the complete human platelet-endothelial cell adhesion molecule-1's in lacking one or more segments near the C-terminus encoded by exons 10-15 of the genes for the full length molecules and arise in vivo from alternative splicing of the transcript from the genes.

Therapeutic use of platelet-endothelial cell adhesion molecule-1

A glycoprotein, PECAM-1, and variants thereof can be obtained by expression in a transformed host cell of a polynucleotide coding for the glycoprotein or a variant polypeptide. PECAM-1 can also be isolated from cellular sources. An antibody specific for PECAM-1 or a PECAM variant can be produced via recombinant techniques, or can be obtained from a hybridoma.

Polynucleotides encoding platelet endothelial cell adhesion molecule

Isolated polynucleotide molecules and peptides encoded by these molecules can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications, relating to human platelet Pen polymorphism. By analyzing genomic DNA or amplified genomic DNA, or amplified cDNA derived from platelet mRNA, it is possible to type glycoprotein GPIIIa with regard to the Pen polymorphism, for example, in the context of diagnosing and treating clinical syndromes associated with GPIIIa-related immune responses.

Methods and kits for determining the pen polymorphism of human platelet

A method and apparatus for dynamically shifting between switching and routing packets efficiently to provide high packet throughput. The present invention provides a method for transmitting packets between an upstream node and a downstream node in a network that utilizes flow classification and labelling to redirect flows. The method includes the steps of establishing default virtual channels between the upstream node and the downstream node, receiving a packet at the downstream node, performing a flow classification at the downstream node on the packet to determine whether the packet belongs to a specified flow that should be redirected in the upstream node, selecting a free label at the downstream node, and informing the upstream node that future packets belonging to the specified flow should be sent with the selected free label attached. Other embodiments of the present invention include a basic switching unit, a switch gateway unit, and a switching agent for use in a system for transmitting packets in a network. Another embodiment includes system software, fixed on tangible media, that performs flow classification of packets to enable flow labelling and redirection to dynamically shift between Layer 3 IP packet routing and Layer 2 switching to optimize packet traffic throughput. A further embodiment provides a method for switching a flow at a first node in a network.

Method and apparatus for dynamically shifting between routing and

Platelet cell adhesion molecule and variants thereof

A method and apparatus for dynamically shifting between switching and routing packets efficiently to provide high packet throughput. The present invention provides a method for transmitting packets between an upstream node and a downstream node in a network that utilizes flow classification and labelling to redirect flows. The method includes the steps of establishing default virtual channels between the upstream node and the downstream node, receiving a packet at the downstream node, performing a flow classification at the downstream node on the packet to determine whether the packet belongs to a specified flow that should be redirected in the upstream node, selecting a free label at the downstream node, and informing the upstream node that future packets belonging to the specified flow should be sent with the selected free label attached. Other embodiments of the present invention include a basic switching unit and a switch gateway unit for use in a system for transmitting packets in a network. Another embodiment includes system software, fixed on tangible media, that performs flow classification of packets to enable flow labelling and redirection to dynamically shift between Layer 3 IP packet routing and Layer 2 switching to optimize packet traffic throughput. A further embodiment provides a method for switching a flow at a first node in a network.

Reactive congestion control in an asynchronous transfer mode (ATM) network where the network is formed by the interconnection of nodes each including a forward path for transfer of information from source to destination through the network and a return path for returning congestion control signals. Each source includes a modifiable issue rate unit which issues forward information signals at different rates for virtual channels in response to the presence and absence of congestion signals received on the return path.

Method and apparatus for reactive congestion control in an asynchronous

Polynucleotides for determining the pen polymorphism of human platelet

Isolated polynucleotide molecules, and peptides encoded by these molecules, can be used in the analysis of alloantigen phenotypes, as well as in diagnostic and therapeutic applications relating to human platelet Pl.sup.A polymorphism. In this vein, a method for typing blood cell and platelet membrane glycoproteins entails an analysis of amplified cDNA, encoded by platelet and red blood cell mRNA.

Growing community of inventors

Shorewood, WI, United States of America

Peter J Newman