University of Iowa Research Foundation

Duke University

Peter J Mohler

Douglas R Spitz, Jr

Mark E Anderson

Jeffrey Robert Erickson

Anthony Gramolini

Vann Bennett

Calcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antibodies that bind specifically to oxidized forms of CaMKII (oxCaMKII) were generated and were utilized to detect oxCaMKII in blood from: (1) mice with cancer; (2) mice with a knock out of the gene encoding methionine sulfoxide reductase; (3) mice injected with angiotensin II; (4) mice injected with bacterial endotoxin; (5) mice fed a pro-oxidant (ketogenic) diet; and (6) mice with cancer that had been treated with experimental therapy.

Methods of detecting oxidized calcium/calmodulin dependent protein kinase II

Monoclonal antibodies specific for oxidized calcium/calmodulin dependent protein kinase II

The present invention relates, generally, to inositol 1,4,5-triphosphate receptors (IP3R), and, in particular, to methods of modulating the activity of 220 kDa ankyrin-B in cellular localization and physiological function of IP3R. The invention further relates to methods of identifying compounds suitable for use in such methods and to compounds so identified.

Methods of modulating localization and physiological function of IP3 receptors

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Iowa City, IA, United States of America

Peter J Mohler