Harbor Branch Oceanographic Institution, Inc.

Florida Atlantic University

Other

Harbor Branch Oceanographic

Peter J McCarthy

Shirley A Pomponi

Amy E Wright

Ross E Longley

Sarath P Gunasekera

Ying Hai Chen

Nanda K Gulavita

Yoel Kashman

Claude P Selitrennikoff

Neal S Burres

May S Lui

Geewananda P Gunawardana

Malika Gunasekera

Susan H Sennett

Esther A Guzman

H Howard Sun

Shinichi Sakemi

Dedra Harmody

Keith Brian Killday

Katherine Chilson

Rebecca Schimoler

Sarath P Gunaskera

The subject invention provides novel compositions of biologically active compounds which can advantageously be used in blocking cellular proliferation and/or treatment of cancer. Exemplified are: 

Biologically active aphrocallistin compounds

The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

Biologically active lasonolide compounds

Biologically active neopeltolide compounds

The novel compositions and methods of the subject invention can be used in antifugal applications. The antifugal agents of the subject invention can be used in the treatment of an animal or human having a fugal infection. In a further embodiment the compounds can be used to treat plant fugal infections, disinfect surfaces, and prevent spoilage of organic compositions such as food and cosmetics.

Cyclic peroxides as novel antifungal agents

The subject application concerns novel compounds with useful biological properties. For example, these compounds can be used as antinflammatory, anti-proliferative, immunomodulatory, and/or neuroprotective agents. Specific examples of the compounds of the subject invention include Secobatzelline A and Secobatzelline B, which can be isolated from marine sponges.

Aminoiminoquinone and aminoquinone alkaloid compounds and methods of use

Discorhabdin compounds are derived from marine sponges of the genus Batzella or prepared by synthetic methods. These compounds, and pharmaceutical compositions containing them as active ingredients, are useful as immunomodulatory, antitumor agents, and/or caspase inhibitors.

Discorhabdin compounds and methods of use

A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial and antitumor agents.

Antitumor and antibacterial peptide and methods of use

A novel peptide, polydiscamide A, has been isolated from a marine sponge. This compound, and its derivatives, are useful as antibacterial agents.

Antibacterial peptide and methods of use

Novel heterocyclic alkaloids were isolated from a marine sponge. These compounds, and derivatives thereof, are useful antifungal and antitumor compounds. The novel compounds have the following structures: ##STR1## wherein R.sub.1 =H, alkyl, alkenyl, aryl, benzyl, acyl, benzoyl, or alkali metal;

Bioactive heterocycle alkaloids and methods of use

A novel lactam discodermide has been isolated from a marine sponge. This compound, and its derivatives, are useful as antifungal and antitumor agents.

Novel bioactive discodermides and methods of use

Novel brominated bisindole-imidazole alkaloids have been isolated from marine sponges. These compounds, and derivatives thereof, are useful antimicrobial and antitumor compounds.

Bis-indole imidazole compounds which are useful antitumor and

Novel sesterterpene compounds are derived from marine sponges of the genus Ircinia. These compounds and pharmaceutical compositions containing them as active ingredients are useful in the treatment of fungal infections.

Growing community of inventors

Vero Beach, FL, United States of America

Peter J McCarthy