Abbott Laboratories Corporation

Peter J Karabatsos

Mark A Hayden

Andrew G Fischer

Jeffrey B Huff

Sophie Laurenson

Shelley R Holets-McCormack

John D Robinson

Anthony Scott Muerhoff

Thomas P Leary

Qiaoqiao Ruan

Sergey Y Tetin

Mark R Pope

John M Robinson

Pathik H Soni

Lyle Yarnell

M Felicia Bogdan

Edna Prieto-Ballengee

Lei Qiao

Richard Haack

Dustin House

Gavin A Cloherty

Andrew S Schapals

Ka-Cheung Luk

Mary Kuhns

Stefan Hershberger

M Shawn Murphy

Thomas Leary

Andrew T Fischer

Edna M Prieto-Ballengee

Felicia Bogdan

Shelley R Holets-Mccormack

Andrew (andy) Fischer

Provided herein are compositions, systems, and methods for assessing and monitory disease stage and phases, predicting likelihood of disease progression, and predicting and monitoring responses to disease therapies (e.g., in HBV infection).

HBV diagnostic, prognostic, and therapeutic methods and products

Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.

Devices and methods for sample analysis

Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

Growing community of inventors

Glencoe, IL, United States of America

Peter J Karabatsos