Corning Incorporated

Other

Peter J Kalal

Ye Fang

Joydeep Lahiri

Steven J Jonas

Mark Alejandro Quesada

Anthony Glenn Frutos

Michael Edward Badding

Raja Rao Wusirika

Youchun Shi

Wei Wang

Christopher J Chase

The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel, a receptor serine/threonine kinase or a receptor tyrosine kinase.

Arrays of biological membranes and methods and use thereof

A solid oxide fuel cell device comprises: (a) zirconia based electrolyte; (b) at least one ectrode situated on the electrolyte; (c) a component situated in close proximity to the electrolyte, the component comprising at least one metal or metal oxide capable, at temperatures of above 625&#xb0; C., of: (i) migrating to the surface of this component, and (ii) being re-deposited on said at least one electrode; and (d) a protective coating situated on at least one surface of this component. The protective coating substantially prevents the at least one metal or metal oxide from leaving the surface of the component, which is situated under said protective coating. The protective coating is also being substantially impermeable to oxygen.

Solid oxide fuel cell device with a component having a protective coatings and a method for making such

The present invention overcomes the problems and disadvantages associated with prior art arrays by providing an array comprising a plurality of biological membrane microspots associated with a surface of a substrate that can be produced, used and stored, not in an aqueous environment, but in an environment exposed to air under ambient or controlled humidities. Preferably, the biological membrane microspots comprise a membrane bound protein. Most preferably, the membrane bound protein is a G-protein coupled receptor, an ion channel or a receptor tyrosine kinase.

Methods, apparatus and substrates for the detection of reactions between biomolecules or cells and a second compound are disclosed. The invention detects interactions between ligands and receptors by utilizing detecting the diffusion of a species proximate a sensing area. Absorbance detection and diffraction sensors are utilized to monitor the rate of diffusion from the sensing area.

Apparatus and methods for determining biomolecular interactions

Optical sensors and methods are disclosed. The resonance energy transfer between a donor and acceptor pair on a surface is monitored. The change in resonance energy transfer as a function of the change in refractive index of a sensing area disposed between the donor and acceptor pair is utilized to provide various sensing methods and structures.

Growing community of inventors

Corning, NY, United States of America

Peter J Kalal