Millennium Pharmaceuticals Limited

Canthera Therapeutics Inc.

The General Hospital Corporation

Massachusetts General Hospital Corporation

Peter J Elliott

Michael Andrew Foley

Anna I Mandinova

Stephen J Brand

Robert J Gould

Julian Adams

Louis Plamondon

Francois Soucy

Ross L Stein

Vito J Palombella

Sam W Lee

Eric S Lightcap

Alfred L Goldberg

Lawrence R Dick

Gopalakrishna R Vaddi

Dan R Burns

Teresa A McCormack

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Compounds and compositions for treating cancer

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed. A representative compound according to the invention is: 

The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.

Method for monitoring proteasome inhibitor drug action

This invention is directed to treating ischemia by administering proteasome inhibitors, ubiquitin pathway inhibitors, agents that interfere with the activation of NF-&kgr;B via the ubiquitin proteasome pathway, or mixtures thereof.

Treatment of infarcts

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Marlborough, MA, United States of America

Peter J Elliott