The Brigham and Women's Hospital, Inc.

Charité – Universitätsmedizin Berlin

Peter Hufnagl

George Mutter

Sebastian Lohmann

David James Papke, Jr

Systems and methods are provided for augmenting digital analysis of lesions. An image of tissue having a glandular epithelial component is generated. The image represents a plurality of medium-scale epithelial components. For each of a plurality of cells within the image, a representative point is identified to provide a plurality of representative points for each of the plurality of medium-scale epithelial components. For each of a subset of the plurality of medium-scale epithelial components, a graph connecting the plurality of representative points is constructed. A plurality of classification features is extracted for each of the subset of medium-scale epithelial components from the graph constructed for the medium-scale epithelial component. A clinical parameter is assigned to each medium-scale epithelial component according to the extracted plurality of classification features.

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Berlin, Germany

Peter Hufnagl