The Charles Stark Draper Laboratory, Inc.

Peter Hsi

Jason Oliver Fiering

Vishal Tandon

Charles A Lissandrello

Jenna Leigh Balestrini

Rebecca Christianson

Ryan A Dubay

Transfer of genetic and other materials to cells is conducted in a hands-free, automated and continuous process that includes flowing the cells between electroporation electrodes to facilitate delivery of a payload into the cells, while acoustophoretically focusing the cells. Also described is a control method for the acoustophoretic focusing of cells that includes detecting locations of cells flowing through a channel, such as with an image analytics system, and modulating a drive signal to an acoustic transducer to change the locations of the cells flowing in the channel. Finally, an electroporation driver module is described that uses a digital to analog converter for generating an electroporation waveform and an amplifier for amplifying the electroporation waveform for application to electroporation electrodes.

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Waltham, MA, United States of America

Peter Hsi