Wyeth Holdings Corporation

De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur

De Staat Der Nederlanden, Vert. Door De Minister Van Vws

De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Welzijn,

De Staat Der Nederlanden

Peter Hoogerhout

Jan T Poolman

Peter Andre Van Der Ley

Peter R Paradiso

Robert C Seid, Jr

Emmanuel J H J Wiertz

John Edward Heckels

Ian Nicholas Clarke

Constant A Van Boeckel

Eduard C Beuvery

Jacobus H Van Boom

Gerarda Petronella Johanna Maria Van Den Dobbelsteen

Adolf Evenberg

Gerarda Petronella J M Van Den Dobbelsteen

The invention relates to an improved vaccine to treat Alzheimer's disease.

Vaccine against amyloid folding intermediate

Outer-membrane vesicles, Class 1 outer membrane proteins offragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal disease.

Recombinant microorganism expressing meningococcal class 1 outer membrane protein

Outer-membrane vesicles, Class 1 outer membrane proteins of, fragments or oligopeptides containing epitopes of the Class I OMP can be used to immunize against meningococcal disease.

Meningococcal class 1 outer-membrane protein vaccine

A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula (1): H N&mdash;&lsqb;(CH ) &mdash;CHR &mdash;CR R &mdash;A&rsqb; &mdash;CHR &mdash;(CHR ) &mdash;CHR &mdash;S&mdash;R wherein A is a direct bond or a group having the formula &mdash;&lcub;Z&mdash;(CH ) &mdash;CHR &mdash;CHR R &rcub; Z&mdash;, m is an integer form 0 to 5; n is an integer form 0 to 3; p is an integer from 0 to 2; q is the integer 0 or 1; R is hydrogen or C -C alkyl, optionally substituted by amino, hydroxyl, carboxyl, C -C alkoxycarbonyl, carbamoyl, mono- or di(C -C alkyl)carbamoyl or N-(&agr;-carboxyalkyl)carbamoyl, or, if m &ne;0, R is hydroxyl, amino or peptidylamino; R and R are independently hydrogen or C -C alkyl, or together from an oxo group; R is hydrogen, C -C alkyl, carboxyl, C -C alkoxycarbonyl, carbamoly, mono-or di(C -C alkyl)carbamoyl or N-(&agr;-carboxyalkyl) carbamoyl; R is hydrogen, methyl, hydroxy or C -C acyloxy; R is hydrogen or methyl; R is hydrogen or thiol-protecting group or group having the formula &mdash;S&mdash;CHR &mdash;(CHR ) &mdash;CHR &mdash;&lsqb;A&mdash;CR R &mdash;CHR &mdash;(CH ) &rsqb; &mdash;NH ; and Z is imino, methylimino, oxygen or sulphur.

Method of coupling polysaccharides to proteins

Immunogenic meningococcal LPS and other membrane vesicles and vaccine

The invention relates to new oligosaccharides comprising the structure (D-ribose-D-ribitol-phosphate).sub.m, (D-ribitol-phosphate-D-ribose).sub.m or (phosphate-D-ribose-D-ribitol).sub.m, m being 2,3,4 . . . 19 or 20, to immunogens containing such oligosaccharide, to vaccines containing such immunogens and to methods for preparing such oligosaccharides, immunogens and vaccines. The vaccine is very suitable for treating infections caused by Haemophilus influenzae type b.

Oligosaccharides, immunogens and vaccines, and methods for preparing

Growing community of inventors

Bilthoven, Netherlands

Peter Hoogerhout