Hoechst Aktiengesellschaft

Eyesense Ag

Ciba-geigy Corporation

Novartis Ag

Ciba Vision Corporation

Peter Herbrechtsmeier

Werner Groh

Peter Hagmann

Bernhard Seiferling

Gerhard Wieners

Sharla Borghorst

John Golby

Otto Kretzschmar

Achim Müller

Jochen Coutandin

Rudolf Heumuller

Jurgen Theis

Achim Mueller

Harald Bothe

Rudolf Steiner

Monika Knuth

Katharina Nikolaus

Gunter Siegemund

Michele De Lucchi

Jurgen Kuhls

Herbert Fitz

Achim Muller

Manfred Tschacher

Torsten Fritze

Hans Schafer

Roger Biel

Axel Heinrich

Horst Schafer

Peter Hofer

Klaus Haberstroh

Werner Steffan

Roman Gruler

Erich Baumann

Masahiko Cubo

Achim M&uuml;ller

Klaus Hintzer

Beat Muller

Thomas Stehlin

Manfred Koch

Peter Blickle

Beat Müller

Beat M&uuml;ller

Wolfgang Grunbein

Roland Hauck

Gerhard Wenz

Egbert Jux

Wolfgang Wendel

Karl Baur

Manfred Fleissner

Martin Reichner

Anette Therese Lang-Sch&ouml;ll

David Pietrobon

Gunter Greiner

Norbert Nix

Masahiko Kubo

Anette Lang

Herbert Vilcsek

Erich Bauman

Klaus Wenke

Rainer Freudenberger

Arnulf-Dieter Schluter

Thomas Schulz

Iris Jlona Leder-Br&uuml;ck

Wilhelm H&ouml;rner

Norbert S&ouml;llner

Norbert Söllner

Wolfgang Hofmann

The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.

Device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein

The invention relates to a sensor element for detecting at least one analyte in a body fluid or in a body tissue, particularly for determining at least one metabolite concentration in a body fluid. The sensor element comprises an implantable, one-piece shaped body, which comprises a sensor end and a coupling end. The shaped body comprises, in the area of the sensor end, at least one sensor area, which comprises at least one sensor material. The sensor material changes at least one optically measurable property in the presence of the analyte. The shaped body also has at least one optically transparent coupling part, which is designed to transmit electromagnetic radiation in at least one spectral range between the sensor area and the coupling end. In the sensor area, the shaped body has at least one optically transparent matrix material, and the analyte can at least partially diffuse through the matrix material to the sensor material. The sensor material is embedded in the matrix material. The coupling part is formed at least partially by the matrix material.

Implantable sensor element

The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.

Use of hydrogels for biosensors having elevated sensitivity

The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.

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The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.

Implantation device for metabolite sensors

An implant () for detecting at least one analyte () in a body fluid, in particular an eye fluid, is proposed. The implant () is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant () having a hydrogel matrix () with at least one hydrogel (). The implant () also has sensor particles () dispersed in the hydrogel matrix (), the sensor particles () having at least one sensor matrix () with a sensor matrix material () and at least one sensor material ().

Hydrogel implant for sensing metabolites in body tissue

The invention proposes a manual measuring appliance () and an analytical measuring system () which can be used to measure at least one analyte in an eye fluid of an eye (). The handheld measuring appliance () comprises a measuring system () and a positioning system (). The measuring system () can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor () in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system () is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye () and the handheld measuring appliance () and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (), wherein the calibration system () is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.

Device for measuring an analyte in an eye fluid

A measured amount of a material that is crosslinkable by impingement of a suitable form of energy, especially UV light, is introduced into a two-part mould of which the cavity determines the shape of a moulding to be produced. The two mould halves are held a small distance from one another so that a thin annular gap is formed between them, which gap is in communication with the mould cavity and through which gap excess material can escape. The crosslinking is triggered by impingement of the selected form of energy, the impingement being spatially restricted to the cavity by suitable masking so that material disposed outside the mould cavity is not crosslinked. In that manner mouldings are obtained that do not require subsequent mechanical processing, and the mould is reusable. The process is especially, but not, however, exclusively, suitable for the manufacture of contact lenses.

Process for the manufacture of mouldings

The invention proposes a manual measuring appliance () and an analytical measuring system () which can be used to measure at least one analyte in an eye fluid of an eye (). The handheld measuring appliance () comprises a measuring system () and a positioning system (). The measuring system () can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor () in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system () is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye () and the handheld measuring appliance () and also furthermore at least one further positioning co-ordinate. The positioning system () comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.

Apparatus for measuring an analyte in an eye fluid

A measured amount of a material that is crosslinkable by impingement of a suitable form of energy, especially UV light, is introduced into a two-part mould of which cavity determines the shape of a moulding to be produced. The two mould halves are held a small distance from one another so that a thin annular gap is formed between them, which gap is in communication with the mould cavity and through which gap excess material can escape. The crosslinking is triggered by impingement of the selected form of energy, the impingement being spatially restricted to the cavity by suitable masking so that material disposed outside the mould cavity is not crosslinked. In that manner mouldings are obtained that do not require subsequent mechanical processing, and the mould is reusable. The process is especially, but not, however, exclusively, suitable for the manufacture of contact lenses.

Process and device for the manufacture of mouldings and mouldings manufactured in accordance with that process

The invention tackles the problem of improving the production process for contact lenses further, so that the production costs for contact lenses can be reduced further and the production capacities can be increased. To this end, provision is made for the two mould halves, which together form the mould for producing a contact lens, to be fixed to each other and/or detachably connected to each other by means of individual half-mould guide. In conjunction with a cyclic production process, a high degree of automation can be achieved in this way.

Single mould alignment

The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.

Cross-linkable copolymers and hydrogels

Efficient and consistent processes for manufacturing moldings, especially ophthalmic lenses such as contact lenses. The processes comprises a series of improvements, including improvements in the areas of conditions for dispensing liquid prepolymer into lens molds, male and female mold mating, reusable molds, mold cleaning, lens separation from molds (demolding), lens handling, and in-line inspection. Cyclic series of processing steps are also disclosed. Additionally, an improved molding tool is disclosed, with the molding tool including a male mold housing and a female mold housing, each of which have disposed therein a plurality of mold halves.

Molding processes

In a process for the manufacture of mouldings, especially optical lenses, specifically contact lenses (CL), a starting material that is crosslinkable by the impingement of suitable energy is introduced into a mould (1) having a cavity (15), which mould is at least partially permeable to the energy concerned. The starting material is introduced into the cavity in a still at least partially uncrosslinked state, the mould cavity determining the shape of the moulding (CL) to be produced. By means of impingement of the energy concerned, the starting material is crosslinked to an extent sufficient for it to be possible for the moulding (CL) to be released from the mould. The filling of the mould cavity is carried out in the starting material that is still at least partially in the uncrosslinked state.

Process and device for the manufacture of mouldings

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Königstein, Germany

Peter Herbrechtsmeier