Whitehead Institute for Biomedical Research

Microbia, Inc.

Other

Peter Hecht

Brian Cali

Amir Sherman

Gerald R Fink

Kevin T Madden

Steffen Rupp

Cora Ann Styles

Eric Summers

Laura Robertson

Sofie Salama

Radclyffe Roberts

Hiten Madhani

Hsiu-Jung Lo

Eric F Summers

Todd Milne

Thea Norman

John C Royer

Mary Maxon

Jeff Silva

Josh Trueheart

Gerald L Fink

Etchell Cordero

Robert Busby

Doug Holtzman

The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.

Use of sublethal concentrations of anti-invasin compounds to therapeutically or prophylactically treat fungal infections

The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Methods for improving secondary metabolite production in fungi

Disclosed herein are methods for regulating fungal gene expression, and reagents for carrying out those methods.

Regulation of fungal gene expression

Disclosed herein is a chimeric protein comprising a pre-activated transcription factor and a strong transcription activation domain for regulating fungal gene expression, and reagents and methods for constructing and using said protein.

Chimeric pre-activated transcription factors

Growing community of inventors

Newton, MA, United States of America

Peter Hecht