Glaxo Group Limited

Peter Hallett

Christopher J Wallis

Eric W Collington

John Bradshaw

Norman F Hayes

Malcolm Clive Carter

Andrew Jonathan Whitehead

Roy Hornby

Michael David Goodyear

Malcolm Leithead Hill

Alan Wadsworth

P Owen Dwyer

Harry Finch

Ian Waterhouse

David R Marshall

The invention relates to a diastereoselective process for the preparation of compounds of formula (1), wherein W is S, S&boxH;O, SO,or O; X is S, S&boxH;O, SO,or O; R,is hydrogen or acyl, and R,is a purine or pyrimidine base or an analogue or derivative thereof.

Process for the diastereoselective synthesis of nucleoside analogues

A process is described for the preparation of compounds of the formula ##STR1## in which W is C.sub.1-7 alkylene

Preparation of aminocyclopentane acids

Compounds are described of the formula ##STR1## in which R.sup.1 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;

Aminocyclopentanol acids and esters and their preparation and

Compounds are described of the formula ##STR1## where: R.sup.1 is --H or --CH.sub.3,

Aminocyclopentyl ethers and pharmaceutical formulation

Compounds are described of the formulae (1a) and 1b) ##STR1## in which: R.sup.1 is -H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl,

Aminocyclopentanes and their preparation and pharmaceutical formulation

Compounds are described of the formulae (1a) and (1b) ##STR1## in which: --COR.sup.1 is an ester group,

Aminocyclopentane esters and pharmaceutical formulations

Compounds are described of the formula ##STR1## in which --COR.sup.1 is a complex ester or thioester group,

Aminocyclopentane esters and pharmaceutical formulation

Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans--CH.dbd.CH-- or CH.sub.2 CH.sub.2 --;

Prostanoid compounds and pharmaceutical formulations

Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans --CH.dbd.CH-- or CH.sub.2 CH.sub.2 --;

Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;

Growing community of inventors

Royston, United Kingdom

Peter Hallett