American Home Products Corporation

Peter H Wei

Stanley Charles Bell

Ronald J McCaully

Francis J Gregory

Harvey E Alburn

Richard L Fenichel

Richard P Carlson

Elisabeth H Freed, Deceased

Novel .alpha.-phenyl-2-(aza)benzothiazolylthioglycolic acids, derivatives thereof and pharmacologically acceptable salts thereof are disclosed, as well as their use as intermediates in the preparation of 2-substituted-3-hydroxy-thiazolo[2,3-b]-benzothiazolium salts, 2-substituted-thiazolo[2,3-b]benzothiazol-3(2H)-one mesoionic didehydro derivatives, 2-substituted-thiazolo[2',3'-2,3]thiazolo[5,4-b]pyridin-3(2H)-one mesoionic didehydro derivatives and related compounds, and their use as modulators of the immune response.

.alpha.-Phenyl-2-(aza)benzothiazolylthioglycolic acids and derivatives

There are disclosed compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, trifluoromethyl or halo;

Phenylpyrazolidine acetic acid derivatives

.alpha.-Mercaptobenzylacetic acid derivatives of imidazole-containing compounds and analogues thereof, and their use as immunomodulating agents are disclosed.

.alpha.-Mercaptophenylacetic acid derivatives of imidazole-containing

Thioacetonitriles and other derivatives of benzo- and azabenzothiazoles and their use as antiviral agents are disclosed.

Antiviral thiazolo [5,4-b] pyridine compounds

Thioacetonitrile of imidazo- and triazolo pyridines and their use as antiviral agents are disclosed.

Antiviral imidazo- and triazolo-pyridines

The compounds of this invention are designated as quinoxalinyl esters of carbamimidothioic acids and exhibit the pharmacological properties of preventing gastric ulcers, reducing gastric secretions and lowering blood pressure. The compounds have the following structural formula: ##STR1## in which Q is hydrogen or nitro;

Quinoalinyl esters of carbamimidothioic acids

Novel 2-substituted-3-hydroxythiazolo[2,3-b]thiazolium salts, the mesoionic didehydro derivatives thereof and related compounds and their use as modulators of the immune response are disclosed.

2-Substituted-3-hydroxythiazolo(2,3-8)-thiazolium salts and mesoionic

3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-acetic acids, their lactones and related compounds, and their use as immunomodulating agents are disclosed.

3-Hydroxy-3-substituted phenylthiazolo[2,3-b]quinazoline-2-alkanoic

3-Substituted phenythiazolo[3'2':1,2]imidazo[4,5-b]pyridine-2-alkanoic acids and their use as immunomodulating agents are disclosed.

3-Substituted phenylthiazolo[3'2':1,2]imidazo[4,5-b]pyridine-2-alkanoic

Substituted 4-hydroxy-2,3-alkylene thiazolium salts are anti-secretory agents useful in the treatment of peptic ulcer disease.

5-Substituted 4-hydroxy-2,3-alkylene thiazolium salts

Novel 2-substituted-3-hydroxythiazolo[2,3-b]benzo-(and azabenzo)thiazolium salts, the mesoionic didehydro derivatives thereof and related compounds are disclosed, as well as the use thereof as modulators of the immune response.

Modulating the immune response with 2-substituted-3-hydroxythiazolo[2,3-b]b

The use of 3-aryl-thiazolo[3,2-a]benzimidazoles, 3-aryl-imidazo[2,1-b]thiazoles, and related compounds as antineoplastic agents, and/or as enhancers of the immune response is disclosed.

Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related

The antibacterial agents of this invention present the following structural formula: ##SPC1## In which

3-Benzoylpropionamido cephalosporanic derivatives

Compounds of the formula: ##SPC1## Wherein R is hydrogen, lower alkyl, halogen, nitro, trifluoromethyl, or lower alkoxy; and n is 2, 3, or 4; and the non-toxic pharmaceutically acceptable acid addition salts thereof; have CNS-depressant activity.

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Springfield, PA, United States of America

Peter H Wei