Therapeuticsmd, Inc.

Other

Peter H R Persicaner

Julia M Amadio

Brian A Bernick

Janice Louise Cacace

Neda Irani

Frederick D Sancilio

Thorsteinn Thorsteinsson

Annette M Shadiack

Jason D Legassie

Philip B Inskeep

Richard Winneker

Ajay Ghanta

Veeran Gowda Kadajji

Mafruhul Bari

This disclosure provides progesterone formulations, methods of using these formulations, and their related pharmacokinetic parameters. In particular embodiments, the formulations disclosed herein allow for a reduction in the amount of progesterone administered to a patient in need thereof, while still providing the benefits of a larger dosage amount.

Progesterone formulations having a desirable PK profile

Estrogen and progesterone replacement therapies are provided herein. Among others, the following formulations are provided herein: solubilized estradiol without progesterone; micronized progesterone without estradiol; micronized progesterone with partially solubilized progesterone; solubilized estradiol with micronized progesterone; solubilized estradiol with micronized progesterone in combination with partially solubilized progesterone; and solubilized estradiol with solubilized progesterone.

Natural combination hormone replacement formulations and therapies

This disclosure provides pharmaceutical compositions for delivering estradiol to a subject in need thereof, as well as methods of administering the compositions, and methods of using them.

Steroid hormone pharmaceutical formulations

According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

Soluble estradiol capsule for vaginal insertion

According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

Vaginal inserted estradiol pharmaceutical compositions and methods

Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject in need thereof are provided. In some embodiments, the pharmaceutical composition comprises solubilized estradiol, suspended progesterone, and a solubilizing agent comprising a medium chain (C6-C12) oil.

Growing community of inventors

Boca Raton, FL, United States of America

Peter H R Persicaner