Merck Sharp + Dohme Corp.

Albany Molecular Research, Inc.

Peter H Dobbelaar

Ravi P Nargund

Shuwen He

Peter Guzzo

Jian Liu

Iyassu Sebhat

Liangqin Guo

Raman Kumar Bakshi

Linus S Lin

Zhixiong Ye

Bruce Sargent

Alan John Henderson

Christopher L Franklin

Mark Hadden

Tianying Jian

Allan James Goodman

Qingmei Hong

Cheng Guo

Larry Yet

James Dellureficio

Megan Ruenz

James P Dellureficio

Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

Substituted imidazoles as bombesin receptor subtype-3 modulators

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators

Growing community of inventors

Morris Plains, NJ, United States of America

Peter H Dobbelaar