Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Peter Gyory

Gabor Kovacs

Istvan Stadler

Istvan Tomoskozi

Sandor Virag

Peter S Kormoczy

Geza Galambos

Gyorgy Dorman

Lajos T Nagy

Gyula Papp

Tamas U Kallay

Gyorgy Lugosi

Laszlo Szekeres

Vilmos Simonidesz

Jeno Marton

Laszlo Simandi

Jozsef Ivanics

Karoly Kanai

Erzsebet Szalay

Pal Hadhazy

Istvan Jelinek

Gabor Besenyei

Zsuzsanna Nad

Karoly Kanay

Ilona Santa Nee Singola

Marta Lugosi

Peter Kormoczky

Marianna Kovacs

Eva Udvary

Process for the preparation of pharmaceutical compositions

The invention relates to new 7-oxo-PGI.sub.2 -ephedrine salt analogues of the Formula I ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, cis or trans --CH.dbd.CH-- or --C.tbd.C--;

7-oxo-PGI.sub.2 -ephedrine salts and their pharmaceutical compositions

Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.

Selective biologically active 7-oxo-prostacyclin derivatives and

A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formula A 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,

Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives

Growing community of inventors

Budapest, Hungary

Peter Gyory