Danisco US Inc.

Genencor International, Inc.

Danisco US Inc., Genencor Division

Danisco A/s, Genencor Division

Peter Gualfetti

Colin Mitchinson

Frits Goedegebuur

Edmund A Larenas

Paulien Neefe

Andrew Shaw

Anthony G Day

Mats Sandgren

Jerry Stahlberg

Jay Ian Phillips

Paulien Neefe-Kruithof

Traci H Ropp

Described herein are variants ofCBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.

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Disclosed are variants ofCeI7A (CBH1.1),CBH1 variant orCBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

Disclosed are variants ofCel7A (CBH1.1),CBH1 variant orCBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted.

Variant humicola grisea CBH1.1

Disclosed are a number of homologs and variants ofCel7A (formerlycellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.

CBH1 homologs and varian CBH1 cellulase

CBH1 homologs and variant CBH1 cellulases

The present invention relates to novel variant EGIII or EGIII-like cellulases that have improved stability. The variant cellulases have performance sensitive residues replaced to a residue having modified stability.

Variant EGIII-like cellulase compositions

Growing community of inventors

San Francisco, CA, United States of America

Peter Gualfetti