The Feinstein Institutes for Medical Research

University of Minnesota

Baxalta Gmbh

Cytokine Pharmasciences, Inc.

Peter Gregersen

Betty A Diamond

Timothy W Behrens

Simone Mader

Lior Brimberg

Richard J Bucala

John A Baugh

Smita Chitnis

Seamus C Donnelly

Joanita Monteiro

Emily C Baechler

Emily C Gillespie

Laura Warren

Methods of diagnosis and methods of treatment and prevention for autism spectrum disorder are provided using decoy antigens to maternal brain-reactive antibodies.

Decoy antigens to maternal brain-reactive antibodies

Provided is a method of non-invasively diagnosing endometriosis in a subject comprising maintaining or culturing stromal cells, obtained from a menstrual effluent or discharge sample from the subject. Also provided is a method of non-invasively diagnosing fertility in a subject. Also provided is a kit for non-invasively diagnosing endometriosis in a subject. Also provided is a method of treating endometriosis in a subject. Also provided is a method of preventing the progression or development of endometriosis in a subject.

Methods for detecting and treating endometriosis

Inhibition of autism spectrum disorder using decoy antigens to maternal brain-reactive antibodies

Describe herein is a novel CATT-tetranucleotide repeat polymorphism at position &#x2212;817 of the human Mif that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position &#x2212;817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed.

Macrophage migration inhibitory factor (MIF) promoter polymorphism in inflammatory disease

The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, the invention provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls.

Methods for diagnosing systemic lupus erythematosus

This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein.

Systemic lupus erythematosus

Describe herein is a CATT-tetranucleotide repeat polymorphism at position &#x2212;817 of the human Mif gene that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position &#x2212;817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed.

Methods for diagnosing severe systemic lupus erythematosus

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Larchmont, NY, United States of America

Peter Gregersen