Mesoblast, Inc

Paradigm Health Sciences Pty Ltd

Proteobioactives Pty Ltd

Arthropharm Pty. Ltd.

Institute of Nutraceutical Research Pty Ltd.

Emu Products Western Australia Pty. Ltd.

Anthropharm Pty. Limited

Paradigm Biopharmaceuticals Ltd

Peter Ghosh

Silviu Itescu

David Cullis-Hill

Ravi Krishnan

Jack Edelman

Michael Whitehouse

Michael Dawson

Bojang Shen

Athol G Turner

Wayne Gregory Kimpton

Simon Reeves Bailey

This invention relates to a method for generating, repairing and/or maintaining connective tissue in a subject. In one embodiment, the invention relates to a method for generating, repairing and/or maintaining cartilage tissue in a subject. The present invention also relates to a method of treating and/or preventing a disease in a subject arising from degradation and inflammation of connective tissue.

Methods of generating, repairing and/or maintaining connective tissue in vivo

Pharmaceutical and veterinary compositions for oral administration comprising a therapeutically effective amount of at least one coxib together with a therapeutically effective amount of pentosan polysulfate or a pharmaceutically acceptable salt thereof are described. The compositions have application for the prophylaxis or treatment of pain and/or inflammation. There is also described a pharmaceutical or veterinary composition comprising a therapeutically effective amount of at least one coxib. The compositions in at least some forms may be lactose free and/or provided in a non-gelatin capsule. Further, there are provided methods for administration of a therapeutically effective amount of at least one coxib in combination with pentosan polysulfate or a pharmaceutically acceptable salt thereof for the prophylaxis or treatment of pain and/or inflammation.

Methods and compositions for the treatment of pain and/or inflammation

A method for the treatment of bone marrow edema in a mammal comprising administering an effective amount of a polysulfated polysaccharide including salts thereof, to a mammal in need of such treatment.

Treatment of bone marrow edema (OEDEMA) with polysulfated polysaccharides

The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an IgE-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for STRO-1cells and/or progeny thereof and/or soluble factors derived therefrom.

Methods of treating or preventing respiratory conditions

The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.

Protection of progenitor cells and regulation of their differentiation

Treatment of bone marrow edema (oedema) with polysulfated polysaccharides

The present disclosure provides a method for treating or preventing a rheumatic disease, comprising administering a population of cells enriched for STRO-1cells and/or progeny thereof and/or soluble factors derived therefrom.

Methods of treating or preventing rheumatic disease

This invention relates to a method for repair and reconstitution of invertebral discs in a subject which involves administration of STRO-1multipotent cells. The method of the invention is useful in the treatment of spinal conditions characterized by degeneration of the invertebral disc.

Growing community of inventors

Fairlight, Australia

Peter Ghosh