Agilent Technologies, Inc.

The Scripps Research Institute

The University of Edinburgh

University College Cardiff Consultants Limited

Lab901 Limited

Alba Bioscience Limited

Peter Ghazal

Stuart Polwart

Joel Fearnley

Douglas Roy

Paul Alfred Dickinson

Janine Scott Robb

Juraj Petrik

Thorsten Forster

Claire Smith

Ben Stenson

Mizan Khondoker

Colin Campbell

Huang Huang

Sepsis remains a leading cause of morbidity and mortality in neonates worldwide. There is also clinically a low threshold for suspicion of infection in neonates, in particular as presentation varies greatly from very subtle to catastrophic collapse. The lack of reliably sensitive tests and the potential life-threatening consequences of delayed treatment of infection results in the widespread use of empirical antibiotics exposing many infants without infection to broad-spectrum antibiotics. The present invention provides a series of patient-invariant biomarkers for screening neonates and other subjects for infection that predicts bacterial infection with high accuracy; and is further shown to have predictive value in identifying infection in suspected cases with blood-culture negative tests.

Molecular predictors of sepsis

Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.

Apparatus and methods for microfluidic applications

The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested.

Antigen detection

The present invention relates to a recombinant DNA construct comprising a YAC vector and at least a portion of the HCMV genome. The vector is useful as a basic research tool with which to study CMV biology, or as a vaccine with which to immunize a mammalian host against infection by CMV.

Generation of human cytomegalovirus yeast artificial chromosome recombinants

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Edinburgh, United Kingdom

Peter Ghazal