Apotex Pharmachem Inc.

Apotex Inc.

Peter Garth Blazecka

Yajun Zhao

Gamini Weeratunga

Cameron L McPhail

Uma Kotipalli

Sammy Chris Duncan

Craig Stewart

Allan W Rey

Daqing Che

Murali Kondamreddy

Nageib Mohamed

Michael B Johansen

Nalini Nagireddy

Randa E El-Haj

The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3) and (4) useful in the preparation of Tasimelteon (1). 

Processes for the preparation of Tasimelteon and intermediates thereof

This invention provides processes for preparation of 3-alkyl indoles of Formula 1: wherein A, Aand Aare independently selected from the group consisting of: H, X, OR, CN, CONRand C0R; Ris C-Calkyl; Ris H or C-Calkyl; Ris C-Calkyl; LG is a leaving group; X is a halogen; and n is 1, 2 or 3.

Processes for the preparation of 3-alkyl indoles

Provided for in the instant application are two additional forms of rifaximin, namely rifaximin polymorphic forms APO-III and APO-IV. Also provided are allegedly novel processes for preparing the previously disclosed rifaximin polymorphic forms APO-I and APO-II. Rifaximin is a non-aminoglycoside antibiotic that has previously been found to be useful for the treatment of traveller's diarrhea caused bybacteria, as well as in the treatment of irritable bowel syndrome, diverticular disease, hepatic encephalopathy, pyogenic skin infections and as an antibacterial prophylactic prior to colon surgery.

Polymorphic forms of rifaximin

Provided are a cocrystal of Adefovir dipivoxil and nicotinamide as well as a cocrystal of Adefovir dipivoxil and salicylamide cocrystal and processes for the preparation thereof.

Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof

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Brantford, Canada

Peter Garth Blazecka