Cytos Pharmaceuticals LLC

Other

Peter G Thomas

Jose-Luis Diaz

A Michael Wade

Johnny W Peterson

John Peterson

Nutriceutical compositions useful as a dietary supplement which have antioxidant/free radical scavengers and also having a cytoprotective effect are disclosed. The compositions contain a cytoprotective and antioxidant/free radical scavenging amount of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof in combination with phytonutrients having antioxidant properties such as canthanaxin, vitamin A and limonene. The compositions can be prepared in capsule form, tablets, sustained release tablets, suspensions and oral rehydration solutions.

Histidine containing nutriceutical

The present invention relates to methods for alleviating disorders or chronic conditions of the female reproductive system, such as dysmenorrhea, endometrial pain, and pre-term labor, through dietary supplementation with histidine. The invention relates further to novel combination supplements of histidine in conjunction with other nutritional supplement materials which are preferably also useful in alleviating the above-mentioned disorders or conditions. A method for administering a dietary histidine supplement in conjunction with one or more separately formulated therapeutic drugs also known to be useful in treating these female reproductive conditions is also disclosed.

Dietary supplement containing histidine for alleviating dysmenorrhea, endometriosis, and pre-term labor

The present invention relates to methods and compositions for preventing or treating conditions or disorders of the female reproductive system by administering an effective dosage of histidine alone or in combination with other therapeutic agents. The invention relates also to novel physical compositions and delivery devices for administering histidine effectively to a female subject in need of either prophylaxis or treatment of certain disorders of the reproductive system.

Compositions and methods for the prophylaxis and treatment of dysmenorrhea, endometriosis, and pre-term labor, using histidine

The administration of histidine is able to prevent and ameliorate tissue and cellular damage which is caused by damaging levels of cytokines and growth factors. It is shown that histidine, when administered in therapeutic quantities is able to inhibit cytokines and growth factors involved in cell and tissue damage. In addition, the method of adminstering histidine to inhibit these molecules can prevent and ameliorate tissue, vessel and cell damage from restenosis, burns, surgical procedures and other disorders which cause and result from damaged tissues, vessels and cells.

Effective method for the amelioration and prevention of tissue and

Nutriceutical compositions useful as a dietary supplement which have antioxidant/free radical scavengers and also having a cytoprotective effect are disclosed. The compositions contain a cytoprotective and antioxidant/free radical scavenging amount of at least one of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and nutriceutically acceptable salts thereof in combination with phytonutrients having antioxidant properties such as vitamin C, vitamin E, vitamin A and .beta.-carotene. The compositions can be prepared in capsule form, tablets, sustained release tablets, suspensions and oral rehydration solutions.

Histidine containing nutriceutical compositions

The administration of histidine is able to prevent and ameliorate tissue and cellular damage which is caused by damaging levels of cytokines and growth factors. It is shown that histidine, when administered in therapeutic quantities is able to inhibit cytokines and growth factors involved in cell and tissue damage. In addition, the method of administering histidine to inhibit these molecules can prevent and ameliorate tissue, vessel and cell damage from restenosis, burns, surgical procedures and other disorders which cause and result from damaged tissues, vessels and cells.

The present invention relates to methods for protecting the eye from degenerative eye conditions by administering prophylactic histidine compositions. The invention also relates to methods for treating ocular inflammation resulting from various causative agents, by administering therapeutic histidine compositions. The invention relates further still to novel histidine compositions for carrying out the present methods.

Prophylactic and therapeutic methods for ocular degenerative diseases

A method of preventing or reducing fluid and electrolyte losses in mammalian subjects under the effect of a stimulus that directly or indirectly causes such losses, by administering a therapeutically effective amount of D-histidine, L-histidine, a racemic mixture thereof, a non-racemic mixture thereof, and pharmaceutically acceptable salts in conjunction with a carrier. In one embodiment the method is useful in reducing or preventing intestinal tract fluid secretions, and fluid and electrolyte losses associated with diarrhea arising from a number of causative agents, such as infectious diarrheas and non-infectious diarrheas. Various therapeutic regimes of histidine administration and formulation are embodied. Therapeutic compositions of histidine in combination with other medicaments, e.g., those that produce a diarrheal side-effect, are disclosed as another embodiment.

Histidine compositions and methods for treating or preventing infectious

A treatment modality for infectious diseases and pulmonary conditions that result from the inflammatory responses by tissues to infections by microorganisms, including but not limited to viruses, retroviruses, bacteria, or other microorganisms, or toxins that arise from microorganisms comprises administering an effective amount of histidine to the affected subject to combat the disease or the distress condition resulting therefrom.

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Charlottesville, VA, United States of America

Peter G Thomas