Boston Scientific Scimed, Inc.

Incept, LLC

Baronova, Inc.

Boston Scientific Corporation

Peter G Edelman

Amarpreet S Sawhney

Chandrashekhar Prabhakar Pathak

Joseph T Delaney, Jr

Huisun Wang

Daniel Rogers Burnett

James M Anderson

Jeffrey S Lindquist

Mark W Boden

Richard Charles Gunderson

Horng-Ban Lin

Michael Eppihimer

Scott Fisher

David R Wulfman

Steven L Bennett

Patrick Willoughby

Crystal Marie Anderson-Cunanan

Thomas A Wrobel

David A Melanson

Patrick A Haverkost

Jonathan Swift Stinson

Martin R Willard

Paul E Zarembo

Colby Harris

Lawrence D Wasicek

Laura Elizabeth Christakis

Steven L Kangas

Joel N Groff

Afsar Ali

Samuel Robaina

Jan D Seppala

Anthony F Tassoni, Jr

Michelle D Lyman

Jacob Drew Edick

Ari Ryan

Ben Arcand

Husnija Mujkanovic

Nayan Ashar

Eddie Sucgang

Allen UtKe

David Robert Wulfman

Jr Joseph Thomas Delaney

Jan Seppala

Kyle Henderickson

A prosthetic heart valve leaflet includes a plurality of electrospun fibers at least partially embedded in a polymer matrix. The plurality of fibers includes a first polyisobutylene urethane copolymer having a first predetermined weight average percentage of hard segment portions and the polymer matrix includes a second polyisobutylene urethane copolymer having a second predetermined weight average percentage of the hard segment portions, wherein the first predetermined weight average percentage of the hard segment portions is greater than the second predetermined weight average percentage of the hard segment portions.

Prosthetic heart valves having fiber reinforced leaflets

A prosthetic heart leaflet includes a fiber-reinforced structure including a plurality of composite fibers. Each composite fiber includes a core fiber and a sheathing fiber disposed about the core fiber, wherein the core fiber or the sheathing fiber has a curvilinear shape.

Prosthetic heart valve composed of composite fibers

A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.

Prosthetic heart valve formation

A prosthetic heart valve includes a composite material that has a first plurality of fibers embedded in a polymer matrix. Each fiber can have a first extending direction and a plurality of undulations.

Fiber reinforced prosthetic heart valve having undulating fibers

A prosthetic heart valve leaflet is composed of a self-reinforced composite (SRC) structure that includes a first layer. The first layer can include a first plurality of fused fibers composed of a first polymeric material in which each fiber is fused to at least one adjacent fiber by a reflowed fiber domain region.

Prosthetic heart valve including self-reinforced composite leaflets

A prosthetic heart valve includes a plurality of synthetic polymeric leaflets. Each leaflet has a base polymer and a polymer coating at least partially disposed over the base polymer, wherein the polymer coating includes polymerized units of a monomer comprising a zwitterionic group when the polymer coating is exposed to an aqueous environment at a pH of about 7.4.

Synthetic heart valves composed of zwitterionic polymers

The present disclosure is directed to a delivery catheter with a mechanism of discharging an adhesive during and/or immediately prior to deployment of the medical device by the delivery catheter.

Deployment system incorporating application of adhesive

An intravascular catheter is disclosed that includes an elongated shaft defined by a wall including at least one port extending through the wall into a lumen. At least one channel may be defined between layers of polymer making up the catheter shaft. The channel extends along at least a portion of the shaft and is in fluid communication with the port. Outer and inner diameters of the catheter may be substantially constant along the length of the catheter.

Crescent channel dye flow enabled guide catheters

Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.

Ingestible formulations for transient, noninvasive reduction of gastric volume

Intravascular medical devices comprising a coating layer disposed on a substrate associated with the medical device, wherein the coating layer has a pre-determined fragmentation pattern. At least a portion of the coating layer comprises a plurality of discontinuous bioresorbable members, wherein the discontinuous bioresorbable members have a size less than the luminal diameter of an arteriole. The coating layer may be formed by excavating portions of a coating layer (e.g., by laser ablation) to create gaps which define the discontinuous bioresorbable members. In certain embodiments, the coating layer is formed of a heat-bondable material. In such embodiments, the discontinuous bioresorbable members may be adhered to the substrate via heat bonds. Also disclosed are methods of forming a coating layer on medical devices and methods of treating intravascular sites.

Medical devices having a bioresorbable coating layer with a pre-determined pattern for fragmentation

In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.

Endoprosthesis having a non-fouling surface

According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate and (b) bioerodable polymeric layer over the substrate that contains (i) one or more biodegradable polymers, (ii) one or more therapeutic agents, and (iii) one or more plasticizers.

Medical devices having bioerodable layers for the release of therapeutic agents

Growing community of inventors

Maple Grove, MN, United States of America

Peter G Edelman