Randox Laboratories Limited

Randox Teoranta

Other

Peter Fitzgerald

Ivan Robert McConnell

Elouard Benchikh

Philip Andrew Lowry

John Victor Lamont

Stuart Jackson

Paul John Innocenzi

Ciaran Richardson

Martin Reid

Gareth Wilson

Deepesh Upadhyay

Andrew Philip Lowry

Marc Wharry

Michael Hooks

Mark William Ruddock

Cherith N Reid

David Sloan

Carl Wrigglesworth

Konstantinos Makris

Kate E Williamson

Paul Courtney

Catherine McCooke

P Evans

Proinnsias McGleenan

Sophie Visvikis-Siest

Said El Shamieh

Helena Murray

Alex Chacko

Frank Emmert-Streib

Catherine Mccooke

Kenneth Martin

Mohan Sivananthan

Alistair Hall

Ian Pearson

Mark W Ruddock

John Lamont

Elouard Benchik

A pipette tip carrier assembly suitable for storing elongate pipette tips in a biochemical analyser is described. The pipette tip carrier assembly comprises one or more holding elements each adapted to hold, in use, a respective pipette tip oriented such that the elongate dimension of the held pipette tip is parallel to a first axis. The pipette tip carrier assembly also includes a light source arranged to produce, at a position distal to the one or more holding elements along the first axis, light directed towards each of the one or more holding elements so as to be intercepted by one or more pipette tips held in 10 use by the one or more holding elements.

Pipette tip carrier assembly

There is provided a sterilisation assembly for a molecular diagnostic assay analyse. The assembly comprising: an enclosure having a passage therethrough, the passage being arranged in use to allow an assay sample set to pass through the enclosure, the enclosure defining a barrier adapted in use to restrict fluid communication across the enclosure to communication through the passage; and a decontaminator located within the passage, the decontaminator is arranged in use to sterilise contamination in the passage.

Sterilisation assembly

An assay cartridge for use in a molecular diagnostics assay having an assay region; a first end comprising a first engagement member for engaging with a support housing; and a second end comprising a second engagement member for engaging with a support housing. The second engagement member has a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element. The clip has a release element extending from the resilient element actuatable to release the clip from a caddy in use.

Assay cartridge and support housing

There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.

Monitoring device

There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

Pipette tip disposal assembly

The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient. The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.

Determination of glycosylation signature

A substrate comprising a coating of a masking material, and a plurality of discrete reaction zones onto which one or more binding agents are intended to be attached, wherein said zones are uncoated areas on the substrate.

Relating to substrates for the attachment of molecules

The present invention provides a chemiluminescence detector, which comprises an image capture device sensitive to chemiluminescence located within a container. The container has an array of apertures located in a field of view of the image capture device, and each aperture is defined by a through-bore in a wall of the container. The exterior of the container is engagable with a plurality of sample holders, each sample holder being in alignment with a respective aperture when engaged with the exterior of the container. The passage of light into the container through each aperture is restrictable by a closure device, passage of light into the container through the apertures is thereby controllable.

Chemiluminescence detector

The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.

Biomarker-based methods for aiding the diagnosis of stroke

Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide and 3,4,-dichloro-N-[2-(methylamino)cyclohexyl]-N-methylbenzamide, as well as the precursory immunogens, are described.

U-47700 immunoassay

Immunoassay methods and their requisite components for the detection and determination of phenethylamines of the 2C and DO sub-families are described.

Immunoassay for phenethylamines of the 2C and DO sub-families

A biochip well is disclosed, including a vessel containing a well therewithin, the vessel forming at least base and side walls of the well and defining at least one aperture giving access to the well, and further including retaining means for holding a biochip at a predetermined position within the well, the well including a laterally offset region into which the biochip does not protrude when held at the predetermined position by the retaining means. Also disclosed are sealed well assemblies and apparatus and methods for opening sealed wells.

Biochip well, sealed well assembly, cartridge therefor, and apparatus and methods for opening sealed wells

The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke.

Method for aiding differential diagnosis of stroke

The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.

Growing community of inventors

Crumlin, United Kingdom

Peter Fitzgerald