Novo Industri A/s

Peter Faarup

Poul Borrevang

Henning Borge Petersen

Erling Guddal

Jorgen Ilum Nielsen

An improvement in the conversion of penam and cephem compounds to secondary ammonium salts of phosphite amides thereof by reacting as follows: ##STR1## wherein --R, is the non-reacting balance of the penam or cephem compound and ##STR2## ARE NON-REACTING SUBSTITUENTS. Catalytic amounts of H--N&lt; or the hydrogenhalide thereof may be present in the reaction medium.

Process for the preparation of phosphorus derivatives of secondary

Method of recovering high purity cephalexin in high yields from a solution containing cephalexin comprising the steps of reacting said solution with a non-substituted or substituted naphthalene to form a complex with cephalexin, isolating said complex, and decomposing said complex to recover cephalexin or a salt thereof.

Method of preparing a sparingly soluble complex of cephalexin

Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.

Growing community of inventors

Frederiksberg, Denmark

Peter Faarup