Novo Nordisk A/s

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Schering Aktiengesellschaft

Peter Faarup

Anthony Murray

Palle Jakobsen

Anker S Jorgensen

Louis B Hansen

Frederik Christian Gronvald

Erling Guddal

Peter H Andersen

Lone Jeppesen

Jens Breinholt

Thorsten Blume

Kristian Tage Hansen

Preben H Olesen

John Bondo Hansen

Anders Bendtz Kanstrup

Erik B Nielsen

Carsten Enggaard Stidsen

Frederik Gronwald

Christian Grondahl

Jan Lund Ottesen

Flemming E Nielsen

Hans Bundgaard

Jane Marie Lundbech

Frederick Christian Grønvald

Frederik S Gronvald

Henrik Klitgaard

Anker Steen Jo Slashedrgensen

Frederick Christian Gr&oslash;nvald

Frederik Christian Grønvald

Certain novel sterol derivatives can be used for regulating the meiosis in oocytes and in male germ cells.

Meiosis regulating compounds

Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.

The present invention relates to therapeutically active non competitive antagonists, acting selectively at the metabotropic glutamate receptor. The novel compounds are useful in treating diseases in the central nervous system by modulating synaptic transmission via the metabotropic glutamate receptor.

Antagonists, their preparation and use

The present invention relates to 9H-indeno[1,2-b]pyrazin-3(4H)-ones and 9H-indeno[1,2-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof which are useful in treating neurological and psychiatric diseases based on the antagonism of the glycine binding site on the NMDA receptor complex.

Heterocyclic compounds and their preparation and use

The present invention relates to therapeutically active heterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system related to the metabotropic glutamate receptor system.

Thieno[2,3-b-indole derivatives and their use for treating central

9H-indeno[1,2-b]pyrazine derivatives

Novel thieno[2,3-b]pyrazine-2,3(1H,3H)-diones or tautomeric forms thereof of the formula (I) ##STR1## The compounds are useful in the treatment of neurological and psychiatric diseases.

Thieno pyrazine diones, their preparation and use

Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; X represents oxygen or sulfur; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

Aza spiro decane and use thereof in treating CNS disorders

Novel [1]benzothieno[2,3-b]pyrazine-2,3(1H,4H)-diones or tautomeric forms thereof of the general formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, halogen, alkyl, alkoxy or trifluoromethyl. The compounds are useful for treating a central nervous system ailment associated with the NMDA receptor-associated glycine site.

Benzothienopyrazinedione compounds and their preparation and use

1-carboxyalkylquinoxaline-2,3(1H,4H)-dione compounds or tautomeric forms thereof of the formula ##STR1## wherein R represents hydrogen, C.sub.1-6 -alkyl, including branched chains, or aralkyl and n represents the number from 0 to 5;

Quinoxaline-2,3-dione compounds and their preparation and use

Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

Indole derivatives and their use

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Vaerlose, Denmark

Peter Faarup