Other

Isis Pharmaceuticals, Inc.

Boehringer Mannheim Gmbh

Egholm, Michael

Buchardt, Ole

Nielsen, Peter Eigil

Berg, Rolf Henrik

Peter Eigil Nielsen

Michael Egholm

Rolf Henrik Berg

Ole Buchardt

Ole Buchardt, Deceased

Leif Hoejslet Christensen

Liam Good

David J Ecker

John S Kiely

Henrik Frydenlund Hansen

Michael C Griffith

Niels E Mollegaard

James M Coull

Anne B Eldrup

Pernilla Wittung

Benget Norden

By Dorte Buchardt, Legal Representative

Kim L Dueholm

Pierre Lagriffoul

Christopher John Stanley

Gerald Haaima

By Dorte Buchardt, Representative

Muthiah Manoharan

Jesper Lohse

Kelly G Sprankle

Helle Knudsen

By Mrs Buchardt

Frederik Beck

Margit Wissenbach

Leila Malik

Carsten Schou

Soren Holst Sonnechsen

Birgit Kjaeldgaard Giwercman

Dorte Buchardt

By Dorte Buchardt, Executor

Compositions and methods are provided for the nucleic acid mimic determination of nucleic acids. The compositions and methods may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which encode proteins that are implicated in disease states. In accordance with preferred embodiments, mimics are comprised of non-naturally occurring backbones to which are appended modified heterocyclic bases. Such bases preferably have sterically bulky substituents 1, 2, or 3 atoms removed from the sites of attachment to the backbone.

Substituted nucleic acid mimics

The invention concerns compositions comprising a nucleic acid mimic. The compositions may be used in the diagnosis and treatment of diseases amenable through modulation of nucleic acids which encode proteins that are implicated in disease states. In accordance with preferred embodiments, mimics are comprised of non-naturally occurring backbones to which are appended modified heterocyclic bases. Such bases preferably have sterically bulky substituents 1, 2, or 3 atoms removed from the sites of attachment to the backbone.

Admixture comprising a target molecule and a nucleic acid mimic comprising sterically bulky substituents

A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Peptide nucleic acids with polyamide-containing backbones

A novel class of peptide nucleic acids are described which include a conjugate attached thereto. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Peptide nucleic acid conjugates

Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.

Higher order structure and binding of peptide nucleic acids

Methods of and compositions for killing or inhibiting the growth of a bacteria are disclosed. The methods comprise the use of peptide nucleic acids that are targeted to mRNA and/or rRNA. In certain embodiments, methods include the use of one or more separate antibiotics.

Peptide nucleic acids having antibacterial activity

Synthetic procedures for peptide nucleic acids

Peptide nucleic acid synthons

A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility

Novel peptide nucleic acid (PNA) oligomers and their constituent monomers are disclosed. The PNA oligomers and linked PNAs form triple stranded structures with nucleic acids that show an increased specificity for thymidine in nucleic acid targets relative to naturally occurring nucleobases.

Peptide nucleic acid monomers and oligomers

A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C -C alkylamine side chains.

Peptide nucleic acids having 2,6-diaminopurine nucleobases

A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

Modulation of cellular transcription factor activity

The present invention relates to novel drugs which may be used in combating infectious micro-organisms, particularly bacteria. More specifically, the invention relates to peptide nucleic acid (PNA) sequences that are modified by conjugating cationic peptides to the PNA moiety in order to obtain novel PNA molecules that exhibit enhanced anti-infective properties.

Modified peptide nucleic acid (PNA) molecules

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

Peptide nucleic acids

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Kokkedal, Denmark

Peter Eigil Nielsen