National University of Singapore

University of Mysore

Bangalore University

Cambridge Enterprise Limited

Peter Edward Lobie

Vijay Kumar Pandey

Shobith Rangappa

Mohan Chakrabhavi Dhananjaya

Rangappa Kanchugarakoppal Subbegowda

Basappa

Feng Li

Kam Man Hui

Alan Prem Kumar

Muthu Kumaraswamy Shanmugam

Kanchugarakoppal Subbegowda Rangappa

Xiaoyun Dai

Julian Fuchs

Chakrabhavi Dhananjaya Mohan

Amudha Deivasigamani

Hanumantharayappa Bharathkumar

Krishna Bulusu

Gautam Sethi

Bassappa Salundi

Srinivasa Venkatachalaiah

Andreas Bender

The invention relates to compounds of general formula (I): wherein R, n, R, R, and Rare as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer. 

Small molecule inhibitors of BCL-2-associated death promoter (BAD) phosphorylation

Disclosed herein are compounds of Formula I, wherein A, Rto R, and x to z have the meanings given in the description.

Compounds useful in inhibiting human trefoil factor 3

The present disclosure relates to compound of structural Formula I and a method for preparing said compounds. The disclosure further relates to a method of employing the Formula I compounds for modulation of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in cancer cells, and the corresponding use of compound of Formula I as anti-cancer agents.

Compounds as modulator of JAK-STAT pathway, methods and applications thereof

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Singapore, Singapore

Peter Edward Lobie