Janssen Pharmaceutica Nv

Peter De Boer

Wayne C Drevets

Justine M Kent

The present disclosure is directed to, inter alia, methods of treating a subject suffering from or diagnosed with depression, comprising administering to a subject in need of such treatment an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Rto Rare described herein and wherein the compound is administered prior to sleep.

Methods of treating depression using orexin-2 receptor antagonists

The present disclosure is directed to, inter alia, methods of treating a subject suffering from or diagnosed with depression, comprising administering to a subject in need of such treatment an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Rto Rare described herein and wherein the compound is administered prior to sleep. 

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Breda, Netherlands

Peter De Boer