Commonwealth Scientific and Industrial Research Organisation

Peter David East

Stephen Charles Trowell

Chunyan Liao

The invention relates to any assay for the identification of nematicidal compounds such as anthelmintics for the control of nematodes. The assay comprises: (i) incubating a nematode sample (i.e. a 'test nematode sample') containing a pre-determined amount of nematodes with an ingestable substrate labelled with a readily detectable label, under conditions suitable for nematode feeding, wherein said incubation is conducted in the presence of said candidate nematicidal compound or follows a pre-incubation of said nematode sample with said candidate nematicidal compound, and (ii) determining whether said candidate nematicidal compound affects nematode feeding by detecting an increase or decrease in ingested substrate as compared to that which has been ingested by a control nematode sample which has been incubated without said candidate nematicidal compound.

Feeding assay for identifying nematicidal compounds

The invention relates to the identification and isolation of a polynucleotide molecule encoding a new class of protein insecticidal toxin produced by the bacteria. The polynucleotide molecule may be incorporated into, for example, insect-specific viruses (including entomopox and nuclear polyhedrosis viruses), bacteria (includingand), protozoa, yeast and plants for control of pest insects.

Toxin gene from the bacteria photorhabdus luminescens

The invention relates to the identification and isolation of polynucleotide molecules encoding a new class of protein insecticidal toxins which are produced by bacteria from the genera Xenorhabdus and Photorhabdus. The polynucleotide molecules may be incorporated into, for example, insect-specific viruses (including entomopox and nuclear polyhedrosis viruses), bacteria (including Gracilicutes, Firmicutes, Tenericutes and Mendosicutes), protozoa, yeast and plants for control of pest insects.

Growing community of inventors

O'Connor, Australia

Peter David East