General Electric Company

Verification Technologies, Inc.

Sun Chemical Corporation

Peter D Miller

Andrew Michael Leach

Rakesh Vig

Eric Telfeyan

David Brandon Whitt

Anthony Saglimbeni

Richard H Selinfreund

Hongyi Zhou

Reginald Donovan Smith

Nichole Lea Wood

Brian David Polizzotti

Liming Yu

Jan Henrik Ardenkjaer-Larsen

Ewell Cook

Scott Gerger

Henry F McInerney

Radislav Alexandrovich Potyrailo

Ernst Wolfgang Stautner

William Guy Morris

Ronald James Wroczynski

Caibin Xiao

Scott Martell Boyette

David Key Dietrich

John Arthur Urbahn

Junzhong Li

Martin John Bradney

Jan Wolber

Mike Cunningham

Chris Phillips

Junzhing Li

Glenn Alfred Johnson

Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.

Systems and methods for processing complex biological materials

A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.

Methods for dynamic filtration of pharmaceutical products

Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.

Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media

A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.

Fluid path system for dissolution and transport of a hyperpolarized material

An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.

Article, device, and method

A quality control system for measuring parameters in a pharmaceutical product includes a receiver vessel to receive a pharmaceutical product therein. The quality control system also includes a sample tube having a first end attached to the receiver vessel to remove pharmaceutical product from the receiver vessel and an appendage connected to a second end of the sample tube. The appendage includes at least one chamber therein to receive a quantity of pharmaceutical product from the receiver vessel. A valve positioned within the sample tube controls flow of the pharmaceutical product to the appendage and prevents flow of the pharmaceutical product from the appendage back into the receiver vessel. The system also includes a quality control device configured to measure at least one parameter of the pharmaceutical product in at least one of the receiver vessel and the appendage.

Apparatus for quality control analysis of an on-site prepared pharmaceutical product

The present invention provides an apparatus and method for a noninvasive optical determination of the pH of a substance in a compartment in a closed system comprising a compartment wherein a substance resides which is permeable to at least one wavelength of light, a light source and light detecting device configured to obtain spectral data for a substance for at least one wavelength, a processor adapted to determine the pH of the substance by correlating the spectral data with predetermined spectral data for a known substance at a known pH at the at least one wavelength, and wherein the processor is further configured to control the release of the substance from the compartment to its end use.

Apparatus and method for fully automated closed system pH measurement

The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use.

Apparatus and method for fully automated closed system quality control of a substance

Method and system for detecting authenticate products based upon alteration of emission characteristics due to interaction of the emissions with the product and the container.

Security imaging system

Methods for the preparation of 7-(dipropylamino)pheno-thiazin-3-ylidene]-dipropylamine.

Processes for preparing novel methylene blue derivative

A method and system for providing copy-protected optical medium using a substrate having information stored thereon in information pits and information lands, wherein the information lands comprise lands in two different planes.

Optical disk copy-protection using an optically changeable security material

A method and system for providing copy-protected optical medium using transient optical state change security materials capable of changing optical state when exposed to a wavelength of about 630 nm to about 660 nm and software code to detect such change in optical state.

Growing community of inventors

New London, CT, United States of America

Peter D Miller