Genzyme Corporation

Peter D McDonnell

Mukund Shankar Chorghade

Rayomand H Gimi

Paul Wolstenholme-Hogg

Pradeep K Dhal

Robert J Miller

Gary S Rea

Steven C Polomoscanik

Mark F Larrousse

Philip Just Larsen

Chinyere Agbugba

Thomas Huebschle

Peter W Thomas

Thorsten Schmidt

Richard V Bodmer, Jr

Ian Davison

Polydiallylamine copolymers are copolymers comprising monomers of polydiallylamine and either polyvinlyamine or polyallylamine. Polydiallylamine copolymers are often crosslinked. The polydiallyamine copolymers are useful as pharmaceutical compositions and may be used in the treatment of type 2 diabetes and for mitigating the complications of type 2 diabetes.

Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes

A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a substituted thiazoline carboxylic acid ester; optionally hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid; optionally, protecting the carboxyl group; alkylating the thiazoline ring at the 4-carbon position, as indicated in Structural Formula (I), with a compound of the formula R-L, wherein Ris as defined above and L is a leaving group, in the presence of a phase transfer catalyst; and, optionally, deprotecting the carboxyl group. In one embodiment of the present invention, a cinchona-alkaloid derived phase transfer catalyst is used to alkylate a protected substituted thiazoline carboxylic acid.

Synthesis of substituted thiazoline carboxylic acids

This invention relates to a method for purifying and drying a polymer hydrogel. This invention is based in part upon the discovery that rapid drying of polymer hydrogels can eliminate the problem of unacceptable levels of soluble oligomers caused by prolonged thermal treatment. Rapid drying techniques allow drying hydrogels containing more water than was previously considered possible without a loss in product quality. Furthermore, it was discovered that slurries comprising polymer hydrogels and large quantities of water can be spray dried and that spray drying can be conducted with only minimal oligomer formation.

Process for purification and drying of polymer hydrogels

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Bury St Edmunds, United Kingdom

Peter D McDonnell