Vertex Pharmaceuticals, Inc.

Other

Seaman Paper Company of Massachusetts, Inc.

Intel Corporation

Peter D Jones

Michael Aaron Brodney

John Patrick Maxwell

Qing Tang

Dennis James Hurley

Kevin Michael Cottrell

Upul Keerthi Bandarage

Jinwang Xu

Simon Giroux

Adam R Looker

Michael John Boyd

Ales Medek

Yi Shi

Stefanie Roeper

Ronald Lee Grey, Jr

Stephen Andrew Thomson

Lev Tyler Dewey Fanning

Kevin Gagnon

Mac Arthur Johnson, Jr

Philippe Marcel Nuhant

Brad D Maxwell

Diane M Boucher

Cavan McKeon Bligh

Setu Roday

Sarathy Kesavan

Amy Beth Hall

Robert Francis Fimognari, Jr

Veronique Damagnez

Rupa Sawant

Rebecca Jane Swett

Timothy Lewis Tapley

Sarah Carol Hood

Pedro Manuel Garcia Barrantes

Steven M Ronkin

Michael P Clark

Kathy Stavropoulos

Muna Shrestha

Kirk Overhoff

Mariam Zaky

Dave Dexter

Chris Killay

James B Jones

Mei-Hsiu Lai

Marisa Sposato

Siying Liu

Gabrielle Simone Fleming

Robert Daniel Giacometti

Samantha Guido

Derek L Davis

Michael Waldo

Mettachit Navamal

Joshua Kennedy Hussey

Mary Elizabeth Eccles

Bernd Firmbach

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Modulators of alpha-1 antitrypsin

Methods and apparatus for unitizing groups of individual packages into pallet loads, stabilizing the loads and facilitating general movement of the pallets, including the loading and unloading of pallets into and out of transport vehicles, includes wrapping the loads with stretchable crepe paper, rather than conventional plastic wrap material. Crepe paper can be produced and recycled with less environmental impact than plastic wrap. These methods involve a new use for crepe paper, and a new use for conventional plastic-wrapping equipment.

Stretchable shipping/pallet wrap and method for use

Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Implemented preferably within a video camera, a secure data capture device is used to prevent a captured data clip from be fraudulently altered without detection. The secure data capture device performs 'time-bracketing' and/or 'sequence ordering' operations to preserve data integrity through implementation of two registers incorporating a 'State of the Universe' ('SOTU') number and a 'sequence' number, respectively. Time-bracketing is performed by digitally signing a running hash value representing the data clip appended to the SOTU number before the digital signature is 'timestamped'. Sequence ordering is performed by digitally signing the digest of the data frame or multiple data frames along with the sequence number.

Apparatus and method for securing captured data transmitted between two

A self-bleeding multi-stage or single-stage hydraulic cylinder system is disclosed which automatically bleeds entrapped air from within the cylinder each time the cylinder is cycled. The self-bleeding structure preferably includes a fixed elongated tube mounted to the base plate of the cylinder, and an axially moveable elongated tube telescopically mounted on the fixed tube. A biasing compression spring forces the moveable tube upward to a predetermined extent when the cylinder is extended. Upon contraction of the cylinder, air trapped therein is purged or bled from the cylinder through the top end of the axially moveable elongated tube into a fluid reservoir. In the final stage of contraction of the cylinder, hydraulic fluid is forced through the fixed and moveable elongated tubes thereby forcing the remaining air trapped therein out of the cylinder and into the hydraulic fluid reservoir.

Self-bleeding hydraulic cylinder

A fastener member to hold sheets of paper in a stack and ultimately be recycled at the same time the paper stacks are recycled. The fastener comprises a rolled material which is tightly bound to itself to produce a rigid shank for use as a fastening member.

Recyclable paper binding means

Growing community of inventors

Garden City, MN, United States of America

Peter D Jones