Glaxo Group Limited

American Cyanamid Company

Other

Peter D Howes

Derek R Sutherland

Pritom Shah

Charles David Hartley

Deborah Lynette Jackson

David Haigh

Martin John Slater

Gordon H Phillipps

David Noble

Michael V Ramsay

Richard A Fletton

Hazel M Noble

Neil Porter

John B Ward

David I Scopes

Edward P Tiley

Richard Bell

Brian M Bain

Gianpaolo Bravi

Esme J Bailey

Stanley F Dyke

Victoria Lucy Helen Lovegrove

Katrina Jane Wareing

Michael V Ramsey

Rossella Guidetti

Anti-viral agents of Formula (I) wherein:A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, Calkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted Calkyl; J represents Calkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form &#x2014;OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

1-acyl-pyrrolidine derivatives for the treatment of viral infections

Novel anti-viral agents of Formula wherein:

4-(6-membered)-heteroaryl acyl pyrrolidine derivatives as HCV inhibitors

Compounds of formula (1) ##STR1## wherein R.sup.1 represents a methyl, ethyl or isopropyl group; Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## [where R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent &gt;C.dbd.O, &gt;C.dbd.CH.sub.2 or &gt;C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group &gt;C.dbd.NOR.sup.7 is in the E configuration)] or --Y.sup.1 --X--Y.sup.2 represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; R.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent &gt;C.dbd.O or &gt;C.dbd.NOR.sup.7a ( where R.sup.7a is as defined above for R.sup.7); and one of R.sup.8 and R.sup.9 represents an alkoxyalkoxy group optionally interrupted by an oxygen atom or an alkoxy group and the other represents a hydrogen atom or R.sup.8 and R.sup.9 together with the carbon atom to which they are attached represent &gt;C.dbd.NOR.sup.7b (where R.sup.7b is as defined above for R.sup.7), and salts thereof. These compounds may be used to control nematode, acarine, insect or other pests.

Macrolide compounds

Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group; and

Antibiotic compounds and method of use

Pharmaceutical compositions for combatting cancer comprising a compound of formula (I) ##STR1## (wherein R.sup.1 represents a hydrogen atom or a C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl group;

Isoquinoline derivatives

A fuel injection nozzle includes a valve assembly located within a chamber defined in a body part to which fuel is supplied through an inlet. The wall of the chamber is resilient whereby during the initial delivery of fuel to the injection nozzle the wall deflects to store fuel whereby the initial rate of flow of fuel to the engine will be at a reduced rate.

Fuel injection nozzles

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Pinner, United Kingdom

Peter D Howes