3m Innovative Properties Company

Adamis Pharmaceuticals Corporation

Minnesota Mining and Manufacturing Company

Kindeva Drug Delivery, L.p.

Astra Aktiebolag

Peter D Hodson

Adam J Stuart

Stephen J Howgill

Michael K Domroese

Stephen W Stein

Anthony C Wass

Graham R Purkins

Richard D Brewer

Andrew M Bryant

David K Smith

Matthew J Wilby

Bryan Eliot Rolfs

Zhaolin Wang

Benjamin Rush

David J Greenleaf

Herbert C Chiou

Eric A Baum

Jonathan D Toback

Blake D Walburg

Thomas S Robison

Paul E Hansen

Philip A Jinks

Rachel Striebig

Christopher B J Groombridge

David J Cottenden

Gary D Mahon

John P Bunting

Benjamin J Holden

Brian Robert Law

Iain G McDerment

Peter John Houzego

Charles G Thiel

Jason A Graves

Gustavo H Castro

William T Richardson

Anton Kuepper

Christopher G Blatchford

Nicholas C Miller

Simon L Calcutt

Romain U G Guion

Paul A Robertson

Borge R Jensen

Graham V Jackson

Stephen D Helm

Iain G McDERMENT

Anthony C L Wass

Neil Emerton

Paul A Charnock

Murray A Creeke

Philip M Dunn

Stephanie Willis

Stephen Pitson

Stephan W Stein

Matthew A Goring

John Fielding

Rachael V Shaw

Stuart A McGlasson

Anthony W Balkwill

David Jc Steven

Heinz G Klein

Michael B Sivigny

Matthew A Oakley

Christopher BJ Groombridge

David J C Steven

Lorraine E Aleandri-Hachgenei

Stuart A Mcglasson

Wei Wang

Lin Li

Robert Stewart

An inhaler () has a breath actuated trigger mechanism () reactive to an inhalation flow to trigger the release of a substance to be inhaled. The inhaler () has an inspiration flow which is subject to a higher degree of flow governing post-triggering than pre-triggering. This allows the triggering flow rate to be closer to, or even higher than, the governing flow rate of the inhaler.

Inhaler flow control mechanism

A flow governor for use in a medicinal inhaler. The flow governor can include (i) a tubular element that defines at least a portion of an air flow path, the tubular element comprising at least one flexible wall configured to flex inwardly in response to an air flow in the air flow path; and (ii) an internal support structure, located within the tubular element and configured to preserve at least a predetermined cross-sectional area of the air flow path within the tubular element when the at least one flexible wall of the tubular element flexes inwardly.

Flow governors for use in medicinal inhalers

A breath-responsive inhaler having a trigger mechanism for triggering delivery of a medicament to a user, the trigger mechanism including a medicament source, having a primed position in which the inhaler is primed for use and an actuated position in which the medicament source is actuated to dispense a dose of medicament, a toggle mechanism for selectively permitting movement of the source from its primed position to its actuated position, the toggle mechanism comprising a vane positioned in the air flow path, the vane being pivoted about a vane pivot, and wherein the trigger mechanism is triggered by movement of the vane upon inhalation of the user to move the toggle mechanism between a primed condition in which the medicament source is maintained in its primed position by cooperation with the toggle mechanism and an actuated condition in which the toggle mechanism is disengaged from cooperation with the medicament source.

Trigger mechanism for an inhaler

Formulations containing pharmaceutical active agent, propellant, and water at least partially adsorbed on or absorbed within one or more nylon pellets or nylon components of, for example, an inhaler such as a metered dose inhaler. Canisters, typically sealed canisters, containing such formulations. Inhalers, such as metered dose inhalers, containing such canisters. Methods of making and using the same.

Formulation and aerosol canisters, inhalers, and the like containing the formulation

An auto-reset dose release firing system () and a method of using same. The system can include an a stored energy device (); a first plunger () movable between first, second, and third positions, the first plunger configured to be operatively coupled to a medicament canister (); and a second plunger () movable between first and second positions; the first and second plunger being movable with respect to one another and shaped to define an evacuable chamber () therebetween. The first plunger and the second plunger can move together from their respective first positions to their respective second positions, due to a reduced pressure in the chamber, to cause a dose release valve () to fire. After firing, air can be allowed to move into the chamber to allow the first plunger to move with respect to the second plunger to its third position to allow the dose release valve to reset.

Auto-reset dose release firing systems, medicinal inhalers comprising same, and methods of using same

The present disclosure relates to a dose indicator for a pressure-actuated metered dose inhaler (pMDI) device. In an embodiment, the dose indicator comprises a chassis element having a viewing portion, a display element located within the chassis element, a resilient deformable element, and an indexing element having an axis, translation of the indexing element along its axis from a first position to a second position causing deformation of the resilient deformable element in the same direction as translation of the indexing element resulting in generally greater displacement of portions of the resilient deformable element nearer to the axis relative to portions thereof further from the axis, the displacement of the portions of the resilient deformable element in the same direction as translation of the indexing element inducing indexing of the display element from a current position to a subsequent position relative to the viewing portion of the chassis element.

Dose indicators with a resilient deformable element

Dry powder inhaler dose counters capable of making a display move swiftly between digits. In contrast to the progressive movement that occurs in simple gearing mechanisms, there is provided a dry powder inhalation device comprising a housing defining a chamber, a patient port in communication with said chamber, an elongate carrier carrying medicament, an advancement mechanism for advancing a length of the elongate carrier into the chamber, a displacement sensor that advances in association with continuous advancement of the elongate carrier, and a transfer component that converts the advancement of the displacement sensor into intermittent motion of a units dose display.

Dry powder inhaler dose counters

A method for filling a plurality of microdepressions in a major surface of a web with finely divided powder in which the web is fed continuously to and through a powder filling stage including a driven roller. A method of manufacturing an elongate carrier with microdepressions containing finely divided powder comprising steps filling a plurality of microdepressions in a major surface of a web as described, removing from upper surface of the web excess powder not filled within the microdepressions and remaining on areas of the surface between the depressions, and optionally slitting and/or cutting the web in width and/or length.

Powder filling processes

Inhaler

The disclosure describes powder inhalers and dry powder inhaler storage cassettes that include a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance. The compartment is configured such that the preloaded doses are sealed within the compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system. The moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier. The sealing system is in sealing configuration prior to an advancement of the carrier, is relaxed upon an advancement of the carrier and is returned to its sealing configuration at the latest after release of the powder associated with the area of the carrier.

Dry powder inhalers

A pressurized metered dose dispenser () for dispensing an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the dispenser comprising an aerosol container () equipped with a metered dose valve (), where a formulation chamber is defined in part by the internal walls of the container, and wherein the dispenser further comprises a porous, fluid permeable, particulate semi-permeable body () located within the formulation chamber adjacent to the metered dose valve.

Metered dose dispensers with porous body

Dose indicators

Dry powder inhaler dose counters capable of making a display move swiftly between digits, in contrast to the progressive movement that occurs in simple gearing mechanisms.

Growing community of inventors

Breaston, United Kingdom

Peter D Hodson