Centrexion Therapeutics Corporation

Other

Peter D Hanson

Gary Fred Musso

James N Campbell

Drazen Ostovic

Randall Stevens

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Methods and compositions for treatment of pain using capsaicin

A protective boot for an animal's hoof having a flexible covering of a general hollow ungulate shape to fit over a hoof. A protective upper portion is connected to the top of the hollow shape to cover the lower leg of the animal. The upper is of sufficient length to extend above the dewclaws on the animal's leg. Securing fastener, such as a strap or Velcro.RTM. near the top of the upper secures the top of the boot around the reduced diameter portion of the animal's leg located above the dewclaws. A hollow tube extends from the upper to beneath the hoof of the animal. The tubing is provided with a branched end extending to opposite sides of the hoof.

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Prides Crossing, MA, United States of America

Peter D Hanson