University of Southern California

Other

City of Hope

University of Delaware

Peter Conti

Zibo Li

Shuanglong Liu

Mian M Alauddin

Hancheng Cai

John D Fissekis

Kai Chen

Dan Li

George A Olah

David A Horne

G K Surya Prakash

John E Shively

Wentao Zhu

Joseph M Fox

Jinbo Hu

Quanzheng Li

Lin Li

Richard M Leahy

Melissa Blackman

Bing Bai

Francois P Gabbai

Zhanhong Wu

Todd W Hudnall

Tzu-Pin Lin

Shuanlong Liu

Chiun-Wei Huang

Matthew Hassink

Ramajeyam Selvaraj

A method of preparing aCu-BaBaSar-RGDsolution is provided. The method includes lyophilizing a solution of BaBaSar-RGDand adding aCu solution to the lyophilized BaBaSar-RGD.

One step 64Cu-BaBaSar-RGD2 production method

This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer includeF-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using theF-labeled dual mode tracers.

18F labeled BODIPY dye and its derivatives for PET imaging of heart perfusion and others

Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula 

Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same

A thio-selective radioactive labeling agent has the following general formula:*R-L-VS,

Vinylsulfone-based 18F-labeling compositions and methods and uses thereof

A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.

Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes

A medical imaging system for reconstructing quantitative dynamic nuclear medicine images of a subject may include a three dimensional positron emission tomography (3D PET) scanner and a data processing system. The three dimensional positron emission tomography (3D PET) scanner may: perform scans of the subject at each of multiple bed positions, each scan being of only a sub-portion of the subject that is within an axial length covered by the scanner; and generate dynamic list-mode PET data that: represents a total number of photon pairs arriving at each of multiple detector pairs in the 3D PET scanner; and is organized in a list of elements, each element in the list including a detector pair index and an arrival time for each detected photon pair; and acquires PET data using a dynamic PET protocol with at least two scans at each of the multiple bed positions. The data processing system may: reconstruct Patlak slope and intercept images of the subject over an axial length of the subject that exceeds the axial length of each scan of the subject by optimizing a likelihood or penalized likelihood function using the list-mode PET data from at least two scans of the subject at each of the multiple bed positions; and store the reconstructed image in a storage device or displays the reconstructed image on a display system.

Direct patlak estimation from list-mode PET data

A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: 

Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same

This invention provides compounds and compositions useful as imaging tracers for positron emission tomography myocardial perfusion imaging (PET MPI). Compounds in accordance with embodiments of the invention will generally comprise three structural elements: i) a triphenylphosphonium moiety; ii) a chelating element; and iii) a hydrophobic element. The tracer compounds are preferably radiolabeled withCu orF. Also provided are methods for synthesizing the compounds, methods for derivatizing the compounds, and derivatives thereof.

Methods and compositions for positron emission tomography myocardial perfusion imaging

The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies.

Methods and compositions for the rapid synthesis of radiometal-labeled probes

The present invention relates to methods of synthesizingF-FMAU. In particular,F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.

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2'-Deoxy-2&#x2032;-[F]-labeled and 3&#x2032;-deoxy-3&#x2032;-[F]-labeled purine nucleoside analogs such as [F]-FAA and [F]-FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [F]-FAA and [F]-FXA are also provided.

[18F]-furanosylpurine derivatives and uses thereof

The present invention is directed to a convenient method of synthesizing radiolabeled &#x3b1;-trifluoromethyl ketones by a fluorination reaction. The present invention also relates to imaging agents and markers for identifying cell proliferation, or viral infection. The markers and imaging agents including the radiolabeled &#x3b1;-trifluoromethyl ketones that are prepared by the present method.

Growing community of inventors

Pasadena, CA, United States of America

Peter Conti