Medimmune Limited

Peter Cariuk

Andrew Grier Buchanan

Darren Schofield

Matthieu Chodorge

Deepesh Pandey

Fumin Chang

Daniel E Berkowitz

Lewis H Romer

Johanna Husmark

Clare Balendran

Claire Louise Dobson

Albert George Thom

David Llewellyn Rees

Elaine M Hurt

Lorraine Irving

Matthew Robinson

Catherine Huntington

Fiona Cusdin

Margareta Ek

Carina Johansson

Jenny Sandmark

Josquin Nys

Aidan Riley

The invention relates to binding molecules, such as antibodies, that bind to the chemokine receptor CCR9. More particularly, the invention relates to the treatment of CCR9-mediated diseases or conditions such as inflammatory bowel disease (IBD), and methods for the detection of CCR9, which make use of the binding molecules of the invention.

Therapeutic binding molecules

The present disclosure is directed to human GDF-15-binding antibodies and antigen-binding fragments thereof. The antibodies and fragments can be used, for example, to detect human GDF-15 and/or in methods of treating cancer or body weight loss, including cachexia, associated with over-expression of human GDF-15.

Antibodies directed against GDF-15

This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.

Antibodies specific for LOX1 and use in treatment of cardiovascular disorders

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Cambridge, United Kingdom

Peter Cariuk