University of Washington

Peter C Kauffman

Paul Yager

Sinclair S Yee

Barry R Lutz

Elain S Fu

Clement E Furlong

Timothy M Chinowsky

Michael S Grow

Scott D Soelberg

Jared Tritz

Alexei N Naimushin

Lisa Kathryn Lafleur

Samantha A Byrnes

Joshua Davis Bishop

Maxwell Wheeler

Sujatha Kumar

Jared Houghtaling

Tinny Liang

Joshua Buser

Bhushan Toley

Shivani Dharmaraja

Xiaohong Zhang

Gina Fridley

Huy Quang Le

The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

Sequential delivery of fluid volumes and associated devices, systems and methods

The present technology describes various embodiments of devices for processing, analyzing, detecting, measuring, and separating fluids. The devices can be used to perform these processes on a microfluidic scale, and with control over fluid and reagent transport. In one embodiment, for example, a device for performing chemical processes can include a porous wick comprising a pathway defined by an input end, an output end, and a length between the input end and the output end. The pathway is configured to wick fluid from the input end to the output end by capillary action. The device can further include a reagent placed on the pathway. The reagent can be placed in a pattern configured to control a spatial or temporal distribution of the reagent along the pathway upon wetting of the pathway.

Reagent patterning in capillarity-based analyzers and associated systems and methods

This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

Portable and cartridge-based surface plasmon resonance sensing systems

Growing community of inventors

Bainbridge Island, WA, United States of America

Peter C Kauffman