Pfizer Corporation

Pfizer Products Inc.

Peter C Canning

Nigel A Evans

Wayne A Boettner

Kasra Kasraian

Barbara J Kamicker

Renee L Hassfurther

This invention relates to stabilized protein compositions, methods for preparing such stabilized protein compositions, dosage forms for administering such stabilized protein compositions to mammals and methods for preventing or treating infections in mammals by administering such protein compositions to mammals. More particularly, the stabilized protein compositions of the present invention contain therapeutically effective amounts of G-CSF, such as bovine G-CSF, in combination with a stabilizing buffer, such as HEPES, TES or TRICINE, for treating and preventing infections, including mastitis, in cattle.

Stabilized protein compositions

Coccidiosis in a bovine animal is prevented by administration of an effective amount of a macrolide antibiotic.

Treatment or prevention of coccidiosis

Aqueous pharmaceutical solutions suitable for injection into a host, having improved injection site toleration, comprise danofloxacin or its pharmaceutically acceptable salts and a magnesium or zinc compound. The zinc compound in addition requires the presence of a co-solvent.

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Terre Haute, IN, United States of America

Peter C Canning